Registration Dossier

Administrative data

Description of key information

N,N,N',N'-tetrakis-(2-hydroxyethyl) hexanediamide is of very low oral and dermal acute toxicity with an oral LD50 (rat) of > 5000 mg/kg bw (Lampe' and Baldwin, 1988) and a dermal LD50 (rabbit) of > 5000 mg/kg bw (Lampe' and Baldwin, 1988).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Additional information

In the test for acute and dermal toxicity, the test compound
was applied to rats and rabbits at single doses of 5,000 mg/kg body
weight. There were no mortalities or body weight effects in
any of the studies. Diarrhea, observed 4 hours after oral
administration, was the only treatment related clinical
sign. Necropsy revealed no gross changes.

Justification for classification or non-classification

Based on the results of the acute oral and dermal studies and according to the criteria of EC Regulation 1272/2008 N,N,N',N'-tetrakis-(2-hydroxyethyl) hexanediamide has a very low acute toxicity if swallowed or if comes into contact with skin. Therefore, the test item must not be classified.