Registration Dossier
Registration Dossier
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EC number: 405-370-0 | CAS number: 6334-25-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: SNIF file in pdf format received from ECHA
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Approximately Annex V (test substance applied to corneal surface)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 405-370-0
- EC Name:
- -
- Cas Number:
- 6334-25-4
- Molecular formula:
- C14H28N2O6
- IUPAC Name:
- N,N,N',N'-tetrakis(2-hydroxyethyl)hexanediamide
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Amount / concentration applied:
- 100 mg
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 0
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 0
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 0
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 0
- Remarks on result:
- other: Max. duration:h;Max. value at end of observation period
- Other effects:
- No signs of eye irritation were observed at any time during the study
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Executive summary:
Note: All info and data in this end point / section is according to ECHA data as annex of inquiry no 06 -0000021150 -88 -0000
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