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EC number: 247-851-6 | CAS number: 26619-69-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 11, 1999 - January 12, 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with the EC A.8 and OECD 117 guidelines and complied with the principles of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- (1992)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- (1989)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- [1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene
- EC Number:
- 247-851-6
- EC Name:
- [1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene
- Cas Number:
- 26619-69-2
- Molecular formula:
- C15H24O
- IUPAC Name:
- [1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene
- Reference substance name:
- 7,7,8,8-tetramethyloctahydro-2,3b-methanocyclopenta[1,3]cyclopropa[1,2]benzen-4-ol
- Cas Number:
- 29461-20-9
- Molecular formula:
- C15H24O
- IUPAC Name:
- 7,7,8,8-tetramethyloctahydro-2,3b-methanocyclopenta[1,3]cyclopropa[1,2]benzen-4-ol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in the expert statement): Folenox
- Chemical name: 4,4,8,8-Tetramethyloctahydro-4a,7-methanonaphtho[1,8a-b]oxirene (IUPAC)
- Empirical formula: C15H24O
- Structural formula: See IUCLID section 1
Constituent 1
impurity 1
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5.8
- Temp.:
- 35 °C
- Remarks on result:
- other: Non-buffered mobile phase
- Type:
- Pow
- Partition coefficient:
- 630 957
- Temp.:
- 35 °C
- Remarks on result:
- other: Non-buffered mobile phase
- Details on results:
- - The HPLC chromatogram of the test substance shows one main peak, assigned to the main component of the substance. Retention times: 19.341 and 19.347 minutes (average: 19.344 minutes)
- The average retention time of Thiourea was 1.80 minutes
Applicant's summary and conclusion
- Conclusions:
- The log Pow of the substance has been determined as 5.8 using the HPLC method (GLP-compliant study in accordance with EC A.8 and OECD 117).
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