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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
January 11, 1999 - January 12, 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was performed in accordance with the EC A.8 and OECD 117 guidelines and complied with the principles of GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report date:
1999

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
(1992)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
(1989)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
[1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene
EC Number:
247-851-6
EC Name:
[1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene
Cas Number:
26619-69-2
Molecular formula:
C15H24O
IUPAC Name:
[1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene
impurity 1
Chemical structure
Reference substance name:
7,7,8,8-tetramethyloctahydro-2,3b-methanocyclopenta[1,3]cyclopropa[1,2]benzen-4-ol
Cas Number:
29461-20-9
Molecular formula:
C15H24O
IUPAC Name:
7,7,8,8-tetramethyloctahydro-2,3b-methanocyclopenta[1,3]cyclopropa[1,2]benzen-4-ol
Test material form:
liquid
Details on test material:
- Name of test material (as cited in the expert statement): Folenox
- Chemical name: 4,4,8,8-Tetramethyloctahydro-4a,7-methanonaphtho[1,8a-b]oxirene (IUPAC)
- Empirical formula: C15H24O
- Structural formula: See IUCLID section 1

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
5.8
Temp.:
35 °C
Remarks on result:
other: Non-buffered mobile phase
Type:
Pow
Partition coefficient:
630 957
Temp.:
35 °C
Remarks on result:
other: Non-buffered mobile phase
Details on results:
- The HPLC chromatogram of the test substance shows one main peak, assigned to the main component of the substance. Retention times: 19.341 and 19.347 minutes (average: 19.344 minutes)
- The average retention time of Thiourea was 1.80 minutes

Applicant's summary and conclusion

Conclusions:
The log Pow of the substance has been determined as 5.8 using the HPLC method (GLP-compliant study in accordance with EC A.8 and OECD 117).