Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-427-2 | CAS number: 106-72-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The experimentally determined 48 h EC50 was 2.4 mg/L with 95 % confidence limits of 0.53 - 10.4 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.4 mg/L
Additional information
A study was performed to assess the acute toxicity of the test item to Daphnia magna. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (April 2004) No 202, "Daphnia sp., Acute Immobilisation Test" referenced as Method C.2 of Commission Regulation (EC) No. 440/2008. Following a preliminary range-finding test, twenty daphnids (4 replicates of 5 animals) were exposed to an aqueous solution of the test item at nominal concentrations of 1.0, 2.2, 4.8, 10.6 and 23.4 % v/v saturated solution for 48 hours at a temperature of approximately 21°C under semi-static test conditions. The number of immobilized daphnia were recorded after 24 and 48 hours.
Analysis of the freshly prepared test preparations at 0 and 24 hours showed measured test concentrations to range from 0.515 to 14.2 mg/L. A decline in measured test concentrations was observed in the old test media at 24 and 48 hours to between 0.264 and 11.1 mg/L and hence it was considered appropriate to calculate the results based on the time-weighted mean measured test concentration only in order to give a "worst case" analysis of the data.
Exposure of Daphnia magna to the test item gave a 48 h EC50 of 2.4 mg/L with 95% confidence limits of 0.53 - 10.4 mg/L. The NOEC was 0.39 mg/L and the LOEC was 0.93 mg/L. The results from the positive control with potassium dichromate were within the normal range for this reference item.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
