Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
The Freund’s Complete Adjuvant Test and the Open Epicutaneous Test
Author:
Klecak, G.
Year:
1985
Bibliographic source:
Current Problems in Dermatology

Materials and methods

Principles of method if other than guideline:
In an open epicutaneous test in 6–8 guinea pigs, 0.1 ml of 100, 30, 10, 3, 1, or 0.3% 1,1-dimethyl-2-phenylethyl acetate was applied daily for 3 weeks with the site uncovered. Suitable vehicles were suggested as ethanol, acetone, water, petrolatum, and/or PEG. Following induction, the animals were challenged on days 21 and 35 with 0.025 ml of 4% 1,1-dimethyl-2-phenylethyl acetate. The sites were scored 24, 48 and 72 h after exposure.
GLP compliance:
not specified
Type of study:
open epicutaneous test

Test material

Constituent 1
Chemical structure
Reference substance name:
α,α-dimethylphenethyl acetate
EC Number:
205-781-3
EC Name:
α,α-dimethylphenethyl acetate
Cas Number:
151-05-3
Molecular formula:
C12H16O2
IUPAC Name:
1,1-dimethyl-2-phenylethyl acetate
Test material form:
solid

Results and discussion

In vitro / in chemico

Results
Remarks on result:
no indication of skin sensitisation
Remarks:
A challenge concentration of 4% 1,1-dimethyl-2-phenylethyl acetate did not cause any reactions. 1,1-Dimethyl-2-phenylethyl acetate was not sensitizing to guinea pigs

Applicant's summary and conclusion