4,7-dimethyloct-6-en-3-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

April 8, 1986 to April 22, 1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

no

Remarks:

pre-dates GLP

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4,7-dimethyloct-6-en-3-one

EC Number:

219-845-3

EC Name:

4,7-dimethyloct-6-en-3-one

Cas Number:

2550-11-0

Molecular formula:

C10H18O

IUPAC Name:

4,7-dimethyloct-6-en-3-one

Test material form:

liquid

Specific details on test material used for the study:

Batch: 117486
Aspect: slightly yellow liquid
Purity: 98.4%

Test animals

Species:

rat

Strain:

other: Füllinsdorf Albino

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

Three female rats were dosed at 5 ml/kg each.

No. of animals per sex per dose:

3 Females only (in both control and test groups)

Control animals:

yes

Details on study design:

Observations:
Symptoms: Twice at day of treatment and then daily for the nature, onset, and duration of all cross or visible toxic or pharmacological effects as well as rate and time of death (see table 1 of study report).

Body weight: Individual body weights were recorded on the day of treatment, 7th and 14th day of observation period.

Evaluations: Lethal doses (see Table 3 of study report) were estimated from parameters given in Table 2 without use of a statistical model. Means of body weights (see Table 4 of study report) were calculated by a PDP 11/24 computer.

The animals are observed for signs of toxicity for 14 days after intubation. The results and details of observations after treatment are summarised in table 2 of the study report. Animals were deprived of food overnight before treatment. After treatment animals were fed a commercial pelleted diet and water ad lib, and survivors are weighed before killing for post-mortem examination at the end of the two week observation period.

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

> 5 mL/kg bw

Based on:

test mat.

Mortality:

no mortality occurred

Clinical signs:

other: no changes observed

Gross pathology:

no findings observed

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The approximate oral acute LD50 value of Dimethyl Octenone in female rats observed over a period of 14 days was estimated to be greater than 5 ml/kg body weight.

Executive summary:

The approximate oral acute LD50 value of Dimethyl Octenone in female rats observed over a period of 14 days was estimated to be greater than 5 ml/kg body weight.