Registration Dossier
Registration Dossier
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EC number: 925-653-7 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish, juvenile growth test
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- Not applicable, calculated value
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Tha aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitionning of the hydrocarbons between the water and organism.
- GLP compliance:
- no
- Remarks:
- The data were calculated by a computer model
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material - Analytical monitoring:
- not required
- Details on sampling:
- Not applicable (calculated data)
- Vehicle:
- no
- Details on test solutions:
- Not applicable (calculated data)
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Not applicable (calculated data)
- Test type:
- other: QSAR modeled data
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Post exposure observation period:
- Not applicable (calculated data)
- Hardness:
- Not applicable (calculated data)
- Test temperature:
- Not applicable (calculated data)
- pH:
- Not applicable (calculated data)
- Dissolved oxygen:
- Not applicable (calculated data)
- Salinity:
- Not applicable (calculated data)
- Nominal and measured concentrations:
- Not applicable (calculated data)
- Details on test conditions:
- Not applicable (calculated data)
- Reference substance (positive control):
- no
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 0.13 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- No details
- Results with reference substance (positive control):
- No reference substance
- Reported statistics and error estimates:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.13 mg/l based on growth.
- Executive summary:
The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.13 mg/l based on growth.
- Endpoint:
- fish, juvenile growth test
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- Not applicable, calculated value
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Tha aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitionning of the hydrocarbons between the water and organism.
- GLP compliance:
- no
- Remarks:
- The data were calculated by a computer model
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material:
No test surrogate nor analogue material - Analytical monitoring:
- not required
- Details on sampling:
- Not applicable (calculated data)
- Vehicle:
- no
- Details on test solutions:
- Not applicable (calculated data)
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Not applicable (calculated data)
- Test type:
- other: QSAR modeled data
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Post exposure observation period:
- Not applicable (calculated data)
- Hardness:
- Not applicable (calculated data)
- Test temperature:
- Not applicable (calculated data)
- pH:
- Not applicable (calculated data)
- Dissolved oxygen:
- Not applicable (calculated data)
- Salinity:
- Not applicable (calculated data)
- Nominal and measured concentrations:
- Not applicable (calculated data)
- Details on test conditions:
- Not applicable (calculated data)
- Reference substance (positive control):
- no
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 0.091 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- No details
- Results with reference substance (positive control):
- No reference substance
- Reported statistics and error estimates:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.091 mg/l based on growth.
- Executive summary:
The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.091 mg/l based on growth.
- Endpoint:
- fish, juvenile growth test
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- Not applicable, calculated value
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Tha aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitionning of the hydrocarbons between the water and organism.
- GLP compliance:
- no
- Remarks:
- The data were calculated by a computer model
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material - Analytical monitoring:
- not required
- Details on sampling:
- Not applicable (calculated data)
- Vehicle:
- no
- Details on test solutions:
- Not applicable (calculated data)
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Not applicable (calculated data)
- Test type:
- other: QSAR modeled data
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Post exposure observation period:
- Not applicable (calculated data)
- Hardness:
- Not applicable (calculated data)
- Test temperature:
- Not applicable (calculated data)
- pH:
- Not applicable (calculated data)
- Dissolved oxygen:
- Not applicable (calculated data)
- Salinity:
- Not applicable (calculated data)
- Nominal and measured concentrations:
- Not applicable (calculated data)
- Details on test conditions:
- Not applicable (calculated data)
- Reference substance (positive control):
- no
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 0.079 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- No details
- Results with reference substance (positive control):
- No reference substance
- Reported statistics and error estimates:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.079 mg/l based on growth.
- Executive summary:
The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.079 mg/l based on growth.
Referenceopen allclose all
No other information
No other information
No other information
Description of key information
Substance specific data is available for Hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%). Additionally, data is also available for structural analogues, Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), and Hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, aromatics (2-25%). This data is read across to based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) is 0.13 mg/l based on growth.
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) is 0.091 mg/l based on growth.
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) is 0.079 mg/l based on growth.
Key value for chemical safety assessment
Additional information
The aquatic toxicity was estimated using the Petrotox computer model (v. 3.04), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) is 0.13 mg/l based on growth.
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) is 0.091 mg/l based on growth.
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C11 -C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) is 0.079 mg/l based on growth.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
