Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 277-551-0 | CAS number: 73609-36-6
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 50.6 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: Assessment based on the IOEL for hydrogen chloride (8 mg/m³ (8 h TWA) in Commission Directive 2000/39/EC).
- Overall assessment factor (AF):
- 1
- Dose descriptor:
- other: Not required as assessment based on long term OEL.
- AF for dose response relationship:
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for differences in duration of exposure:
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for other interspecies differences:
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for intraspecies differences:
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for the quality of the whole database:
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for remaining uncertainties:
- 1
- Justification:
- Not required as assessment based on long term OEL.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 94.9 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: Assessment based on the short term IOEL for hydrogen chloride (15 mg/m³ (8 h TWA) in Commission Directive 2000/39/EC).
- Overall assessment factor (AF):
- 1
- AF for dose response relationship:
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for other interspecies differences:
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for intraspecies differences:
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for the quality of the whole database:
- 1
- Justification:
- Not required as assessment based on long term OEL.
- AF for remaining uncertainties:
- 1
- Justification:
- Not required as assessment based on long term OEL.
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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