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EC number: 274-397-6 | CAS number: 70209-99-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 Oct 2015 to 28 Oct 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Identification: FAT 92349/B TE
- Source and lot No.of test material: Lot: 26/2014
OTHER SPECIFICS:
- Appearance: Dark blue powder - Key result
- Water solubility:
- 57.8 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 50 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not available
- Details on results:
- Preliminary Visual Estimation of the Water Solubility:
The preliminary visual experiments showed that the water solubility of the test item is between 100 g/L and 200 g/L.
Flask-Method: Average of 3 experiments: 57.8 g/L.
The recovery of 98.6 % indicates a sufficient accuracy of the analytical method. - Conclusions:
- The water solubility of the test item at a temperature of 20 °C was determined to be (without correction for the purity): 57.8 g/L.
- Executive summary:
The water solubility of the test substance was determined in a study conducted according to OECD Guideline 105 and EU Method A.6. For the main test three flasks were prepared with about 2500 mg test item and 4 mL water. The batches were stirred for different times at 30 °C (experiment A for 24 h, experiment B for 48 h, experiment C for 72 h) in tightly closed flasks. After equilibration (further stirring for 24 h at 20 °C) a saturated solution with a precipitate of the test item could be observed. Aliquots were taken and centrifuged (30 minutes with 5000 rpm at 20 °C). Subsequently the solution was filtered over 0.20 μm micro filters. The concentration of the test item in this solution was determined by VIS-spectroscopy (601 nm). The mean of three readings was taken as the value for the water solubility of the test item. Based on the findings of the study, the water solubility of the test item at a temperature of 20 °C was determined to be 57.8 g/L.
Reference
Preliminary Visual Estimation of the Water Solubility
Amount of the test item in mg |
Total volume in ml |
Appearance of mixture |
1000 |
1 |
undissolved |
5 |
undissolved |
|
10 |
undissolved |
|
20 |
dissolved |
The preliminary visual experiments showed that the water solubility of the test item is between 100 g/L and 200 g/L.
Flask-Method
Experiment |
A |
B |
C |
D (blank) |
Amount of test item [mg] |
2500 |
2500 |
2500 |
- |
Stirring time at 30 °C [h] |
24 |
48 |
72 |
72 |
Measured concentration [mg/l] |
57.4 |
57.5 |
58.6 |
- |
Dilution |
0.01ml/10ml |
0.01ml/10ml |
0.01ml/10ml |
- |
Water solubility [g/l] |
57.4 |
57.5 |
58.6 |
- |
Average experiments A to C: 57.8 g/L.
Description of key information
The water solubility of the test substance was determined in a study conducted according to OECD Guideline 105 and EU Method A.6. For the main test three flasks were prepared with about 2500 mg test item and 4 mL water. The batches were stirred for different times at 30 °C (experiment A for 24 h, experiment B for 48 h, experiment C for 72 h) in tightly closed flasks. After equilibration (further stirring for 24 h at 20 °C) a saturated solution with a precipitate of the test item could be observed. Aliquots were taken and centrifuged (30 minutes with 5000 rpm at 20 °C). Subsequently the solution was filtered over 0.20 μm micro filters. The concentration of the test item in this solution was determined by VIS-spectroscopy (601 nm). The mean of three readings was taken as the value for the water solubility of the test item. Based on the findings of the study, the water solubility of the test item at a temperature of 20 °C was determined to be 57.8 g/L.
Key value for chemical safety assessment
- Water solubility:
- 57.8 g/L
- at the temperature of:
- 20 °C
Additional information
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