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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: relevance of parameter unknown; no data on test material

Data source

Reference
Title:
No information
Author:
Beck, B.D, Gerson B, Feldman HA, Brain JD (1983). Lactate dehydrogenase isoenzymes in hamster lung lavage fluid after lung injury. Toxicol Appl Pharmacol 71, 59-71.

Materials and methods

Principles of method if other than guideline:
Fe2O3 was suspended at a concentration of 2.5 % in saline. Then 0.15 ml/100 g bw of the suspension was instilled intratracheally into the lungs of hamsters /(5 animals/group). Lung lavage was performed 24 hr after dust instillationLactate dehydrogenase (LD) levels and isoenzyme patterns were determined in the cell free supernatant fractions of lung lavage fluid.
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
Diiron trioxide
EC Number:
215-168-2
EC Name:
Diiron trioxide
Cas Number:
1309-37-1
Molecular formula:
Fe2O3
IUPAC Name:
Diiron trioxide

Test animals

Species:
hamster, Syrian
Sex:
male

Administration / exposure

Route of administration:
intratracheal
Vehicle:
physiological saline
Frequency of treatment:
single injection
Post exposure period:
24 h
No. of animals per sex per dose:
5

Results and discussion

Any other information on results incl. tables

Iron oxide caused an 4.7 fold increase in toatal enzyme activity in the  
lavage fluid. The pattern was comparable to the LDH isoenzymes from  
abdominal macrophages and was similarly, though less intense, as the  
pattern induced ba quartz.
The effect was interpreted by the authors as a non-specific reaction

Applicant's summary and conclusion

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