Feldspar minerals, hematite and quartz, calcination products of copper mining residues

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: detailed report available

Data source

Reference

Title:

No information

Author:

Lay JC, Zeman KL, Ghio AJ, Bennett WD (2001). Effect of inhaled iron oxide particles on alveolar epithelial permeability in normal subjects. Inhalation Toxicol 13, 1065-1078.

Materials and methods

Type of study / information:

Type of experience: other: alveolar epithelial permeability after inhalation of Fe2O3

Principles of method if other than guideline:

Sixteen healthy subjects inhaled aerosols or iron oxide particles. Alveolar epithelial permeability was assessed by measuring the pulmonary clearance of an inhaled radiolabeled tracer molecule using a gamma camera at 0.5 and 24 h post particle exposure. Carbon monoxide lung diffusing capacity and spirometry were also performed before and after breathing the iron oxide

Test material

Test material information

Constituent 1

Reference substance name:

Diiron trioxide

EC Number:

215-168-2

EC Name:

Diiron trioxide

Cas Number:

1309-37-1

Molecular formula:

Fe2O3

IUPAC Name:

Diiron trioxide

Details on test material:

TS-Freetext:
Fe2O3; particle size = 1.5 µm

Results and discussion

Results:

RS-Freetext: Neither ironoxide with high nor low content of soluble iron had any effect on the permeability of the respiratory epithelium in humans