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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: detailed report available

Data source

Reference
Title:
No information
Author:
Lay JC, Zeman KL, Ghio AJ, Bennett WD (2001). Effect of inhaled iron oxide particles on alveolar epithelial permeability in normal subjects. Inhalation Toxicol 13, 1065-1078.

Materials and methods

Type of study / information:
Type of experience: other: alveolar epithelial permeability after inhalation of Fe2O3
Principles of method if other than guideline:
Sixteen healthy subjects inhaled aerosols or iron oxide particles. Alveolar epithelial permeability was assessed by measuring the pulmonary clearance of an inhaled radiolabeled tracer molecule using a gamma camera at 0.5 and 24 h post particle exposure. Carbon monoxide lung diffusing capacity and spirometry were also performed before and after breathing the iron oxide

Test material

Constituent 1
Chemical structure
Reference substance name:
Diiron trioxide
EC Number:
215-168-2
EC Name:
Diiron trioxide
Cas Number:
1309-37-1
Molecular formula:
Fe2O3
IUPAC Name:
Diiron trioxide
Details on test material:
TS-Freetext:
Fe2O3; particle size = 1.5 µm

Results and discussion

Results:
RS-Freetext: Neither ironoxide with high nor low content of soluble iron had any effect on the permeability of the respiratory epithelium in humans

Applicant's summary and conclusion

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