Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Currently viewing:

Administrative data

exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: detailed report available

Data source

No information
Lay JC, Zeman KL, Ghio AJ, Bennett WD (2001). Effect of inhaled iron oxide particles on alveolar epithelial permeability in normal subjects. Inhalation Toxicol 13, 1065-1078.

Materials and methods

Type of study / information:
Type of experience: other: alveolar epithelial permeability after inhalation of Fe2O3
Principles of method if other than guideline:
Sixteen healthy subjects inhaled aerosols or iron oxide particles. Alveolar epithelial permeability was assessed by measuring the pulmonary clearance of an inhaled radiolabeled tracer molecule using a gamma camera at 0.5 and 24 h post particle exposure. Carbon monoxide lung diffusing capacity and spirometry were also performed before and after breathing the iron oxide

Test material

Constituent 1
Chemical structure
Reference substance name:
Diiron trioxide
EC Number:
EC Name:
Diiron trioxide
Cas Number:
Molecular formula:
Diiron trioxide
Details on test material:
Fe2O3; particle size = 1.5 µm

Results and discussion

RS-Freetext: Neither ironoxide with high nor low content of soluble iron had any effect on the permeability of the respiratory epithelium in humans

Applicant's summary and conclusion