Feldspar minerals, hematite and quartz, calcination products of copper mining residues

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Full report available

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

Version / remarks:

Cited as Directive 84/449/EEC, B.1

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Diiron trioxide

EC Number:

215-168-2

EC Name:

Diiron trioxide

Cas Number:

1309-37-1

Molecular formula:

Fe2O3

IUPAC Name:

Diiron trioxide

Details on test material:

IUCLID4 Test substance: other TS: Fe2O3 73.2%, Al2O3 19.5%, Mn2O3 3.0%

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Mortality:

no

Clinical signs:

other: no abnormatlity detected

Gross pathology:

no abnormality detected

Other findings:

no abnormality detected

Any other information on results incl. tables

Mortality: none
Observations: no effects

Applicant's summary and conclusion

Executive summary:

single oral application per gavage, post observation time: 14 days, test substance was applicated in water

result: no mortality, no signs of toxicity