Registration Dossier
Registration Dossier
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EC number: 701-090-0 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: summary- original in chinese
Data source
Reference
- Title:
- No information
- Author:
- Liu L et al. (2004), nano-FeO3-Glu, J Environ Occup Med, 21, 430-43334
Materials and methods
- Principles of method if other than guideline:
- other: see TC
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diiron trioxide
- EC Number:
- 215-168-2
- EC Name:
- Diiron trioxide
- Cas Number:
- 1309-37-1
- Molecular formula:
- Fe2O3
- IUPAC Name:
- Diiron trioxide
- Details on test material:
- IUCLID4 Test substance: other TS: nano-Fe2O3 coated with Glutamic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 42 mg/kg, 21 mg/kg, 10.5 mg/kg
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 250.54 mg/kg bw
Any other information on results incl. tables
LD50 for rats was 250.54 mg/kg. Compared with the control group, organ body coefficient of liver in high and middle dose groups showed significant difference as well as that of lung in female rats in high dose group. The leucocytes of rats and the proportion of neutrophils significantly increased in all treated groups. The platelet in female rats of high dose group increased. The serum creatinine of female rats increased in high dose group. The pathological examination did not show any abnormality in all treated groups.
Nano-FeO3-Glu belonged to common drug, which had not led to pathological changes although it induced certain effect on blood system, liver and kidney function and there is difference in pathological changes between males and females.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
