Feldspar minerals, hematite and quartz, calcination products of copper mining residues

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: well documented and scientifically acceptable

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Reference 2

Reference Type:

other company data

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Diiron trioxide

EC Number:

215-168-2

EC Name:

Diiron trioxide

Cas Number:

1309-37-1

Molecular formula:

Fe2O3

IUPAC Name:

Diiron trioxide

Details on test material:

IUCLID4 Test substance: other TS: Bayferrox VP AC 5046 (73.2% Fe2O3, 19.5% Al2O3, 3% Mn2O3)

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

semiocclusive

Preparation of test site:

shaved

Vehicle:

water

Controls:

not required

Amount / concentration applied:

500 mg

Duration of treatment / exposure:

4 hour(s)

Observation period:

7 d

Number of animals:

3

Results and discussion

In vivo

Results

Irritation parameter:

other: erythema and edema score

Basis:

mean

Time point:

other: 24, 48, 72 h

Score:

0

Max. score:

4

Reversibility:

other: no erythema, no edema

Remarks on result:

other: not- irritant

Any other information on results incl. tables

No skin reaction occurred

Applicant's summary and conclusion

Executive summary:

Patch test in albino rabbits according OECD 404. As a result Bayferrox VP AC 5046 is not irritating