Registration Dossier

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: aim of the study was liver iron content determination after oral feed

Data source

Reference
Title:
No information
Author:
Van Wyk CP, Robbins DJ (1974), Liver iron contents in rats after administration of certain iron compounds, South African Med J 48, 505-509.

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Diiron trioxide
EC Number:
215-168-2
EC Name:
Diiron trioxide
Cas Number:
1309-37-1
Molecular formula:
Fe2O3
IUPAC Name:
Diiron trioxide
Details on test material:
IUCLID4 Test substance: other TS: Fe2O3 (no data on purity)

Test animals

Species:
rat
Strain:
other: BDV BDIX
Sex:
male

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
21 days
Frequency of treatment:
daily (feeding study)
Doses / concentrations
Remarks:
Doses / Concentrations:
112.3, 186.3, 265.5, 330.1 mg/100g diet
Basis:
other: iron intake (mg/100 g average body mass)
No. of animals per sex per dose:
4 per dose
Control animals:
yes
Details on study design:
Post-exposure period: no

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Average iron intake 1120 to 3300 mg/kg body mass; no increase of liver  
non-hemoglobin iron content

Applicant's summary and conclusion