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Registration Dossier
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EC number: 701-090-0 | CAS number: -
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: 1 low dose level only; limited set of investigations (respiratory tract only)
Data source
Reference
- Title:
- No information
- Author:
- Marshall HE, Keenan KP, McDowell EM (1987). The stathmokinetic and morphological response of hamster respiratory epithelium to intralaryngeal instillations of saline and ferric oxide. Fundam Appl Toxicol 9, 705-714.
Materials and methods
- Principles of method if other than guideline:
- weekly repeated intralaryngeal instillation 15 to 20 animals per group
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diiron trioxide
- EC Number:
- 215-168-2
- EC Name:
- Diiron trioxide
- Cas Number:
- 1309-37-1
- Molecular formula:
- Fe2O3
- IUPAC Name:
- Diiron trioxide
- Details on test material:
- IUCLID4 Test substance: other TS: Fe2O3 (Pfizer Chemical, type R3098R, Lot J5)
TS-Freetext:
Fe2O3; purchased from Pfizer Chemical; no further data
Constituent 1
Test animals
- Species:
- hamster, Syrian
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- other: intralaryngeal
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 1, 5, 10, or 15 weeks
- Frequency of treatment:
- once a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 mg/animal/dose
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
No difference of mitotic rate on the tracheal and bronchial
epithelium but in the bronchioles; bronchioalveolar hyper-
plasia after 5 applications and less prominent after 10 or
15 treatments
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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