2,6-dimethylheptan-2-ol

Eye irritation

Administrative data

Endpoint:

eye irritation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Method in Federal Register 38(187)1500.41, S.27029,1973.

GLP compliance:

no

Remarks:

study pre-dates GLP introduction

Test material

Test material information

Constituent 1

Reference substance name:

2,6-dimethylheptan-2-ol

EC Number:

236-244-1

EC Name:

2,6-dimethylheptan-2-ol

Cas Number:

13254-34-7

Molecular formula:

C9H20O

IUPAC Name:

2,6-dimethylheptan-2-ol

impurity 1

Reference substance name:

Unknown impurities

Molecular formula:

not applicable

IUPAC Name:

Unknown impurities

Test material form:

liquid

Specific details on test material used for the study:

Product: 2,6-Dimethylheptanol -2 (liquid)
Substance No.: 77/278

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Test system

Vehicle:

unchanged (no vehicle)

Details on study design:

Primary eye irritation was measured in 6 rabbits. Readings at 24, 48 & 72 hrs and 8 days.

Results and discussion

In vivo

Results

Remarks on result:

probability of moderate irritation

Irritant / corrosive response data:

Primary irritation index: 536 / 18 = 29.8
The pathological findings on the eye and the irritations on the mucous membrane were not reversible within 8 days. Based on the findings the substance must be considered to be moderately irritant.

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

Based on the findings the substance must be considered to be moderately irritant.