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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Method in Federal Register 38(187)1500.41, S.27029,1973.
GLP compliance:
no
Remarks:
study pre-dates GLP introduction

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-dimethylheptan-2-ol
EC Number:
236-244-1
EC Name:
2,6-dimethylheptan-2-ol
Cas Number:
13254-34-7
Molecular formula:
C9H20O
IUPAC Name:
2,6-dimethylheptan-2-ol
impurity 1
Reference substance name:
Unknown impurities
Molecular formula:
not applicable
IUPAC Name:
Unknown impurities
Test material form:
liquid
Specific details on test material used for the study:
Product: 2,6-Dimethylheptanol -2 (liquid)
Substance No.: 77/278

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Details on study design:
Primary eye irritation was measured in 6 rabbits. Readings at 24, 48 & 72 hrs and 8 days.

Results and discussion

In vivo

Results
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Primary irritation index: 536 / 18 = 29.8
The pathological findings on the eye and the irritations on the mucous membrane were not reversible within 8 days. Based on the findings the substance must be considered to be moderately irritant.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
Based on the findings the substance must be considered to be moderately irritant.