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EC number: 436-710-6
CAS number: 756-13-8
Groups of 12 males and 12 females were exposed via inhalation to
concentrations of 0, 300, 1000 and 3000 ppm for 6 hours per day during
the first 2 weeks for 5 days per week, Thereafter, the animals were
exposed until gestation day 19. Male animals were exposed for 4 weeks
and then sacrificed. Females were allowed to litter and were sacrificed
at or shortly after day 4 of lactation. No treatment related mortalities
were seen. Body weights were comparable between the control and exposed
animals during premating, gestation and lactation. Food consumption was
comparable between the control and exposed animals. All females of the
control and exposed groups, except one animal in the low dose group,
became pregnant within 4 days. No treatment related effects were seen in
any of the reproduction parameters. The number of litters with live born
pups was 10, 10, 10 and 12 for the control 300, 1000 and 3000 ppm
groups. The number of pups delivered and the number of pups alive on PN
4 were comparable in all groups. Pup weights on PN 1 and PN 4 were
comparable in all groups. No treatment related observations were
recorded. There were no treatment related differences observed between
the control and exposed animals in absolute and relative testes and
epididymides weights. No gross changes were noted at necropsy. The NOAEC
by inhalation for parental toxicity, fertility, and developmental
toxicity was at least 3000 ppm.
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