Registration Dossier
Registration Dossier
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EC number: 216-644-2 | CAS number: 1633-22-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Dichlorotricyclo[8.2.2.24,7]hexadeca-1(12),4,6,10,13,15-hexaene, mixed isomers
- EC Number:
- 249-236-8
- EC Name:
- Dichlorotricyclo[8.2.2.24,7]hexadeca-1(12),4,6,10,13,15-hexaene, mixed isomers
- Cas Number:
- 28804-46-8
- Molecular formula:
- C16H14Cl2
- IUPAC Name:
- Unknown constituents
- Test material form:
- solid: granular
1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 females/2000 mg/kg bw
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50 cut-off
- Effect level:
- 5 000 mg/kg bw
- Mortality:
- No mortality was observed in rats (set I and II) treated with 2000 mg DPX-C (Di-Cloro-Di-p-Xililene)/kg body weight.
- Clinical signs:
- No clinical sign was observed in all the rats treated with 2000 mg DPX-C (Di-Cloro-Di-p-Xililene)/kg body weight.
- Body weight:
- Normal gain in body weight was observed in all the surviving rats.
- Gross pathology:
- External
External examination of terminally sacrificed rats did not reveal any abnormality.
Internal
Visceral examination of terminally sacrificed rats did not reveal any abnormality.
In absence of any pathological lesion in terminally sacrificed rats, it is concluded that the test item did not produce any treatment related effect at the dose level used in the present study.
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Remarks:
- Category 5 or Unclassified (GHS 2015)
- Conclusions:
- Based on the results of this study, an indication of the classification for DPX-C (Di-Cloro-Di-p-Xililene) is as follows: Globally Harmonized System of Classification and Labelling og Chemicals (GHS 2015): Category 5 or Unclassified.
- Executive summary:
The acute oral toxicity ofDPX-C (Di-Cloro-Di-p-Xililene)was investigated using the acute toxic class method. Female Wistar rats at dosing were given a single oral dose ofDPX-C (Di-Cloro-Di-p-Xililene). The test item was administered in corn oil, following overnight fasting, at dose of 2000 mg/kg body weight andanimalswere observed for 14 days.
There were no treatment-related mortality, clinical sign and changes in body weight or necropsy findings observed.
The acute oral median lethal dose (LD50cut-off value) of DPX-C (Di-Cloro-Di-p-Xililene)in Wistar rats was found to be 5000 mg/kg body weight.
Based on the results of this study, an indication of the classification forDPX-C (Di-Cloro-Di-p-Xililene)isas follows:
Globally Harmonized System of Classification and Labelling of Chemicals (GHS 2015): Category 5 or Unclassified.
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