Registration Dossier
Registration Dossier
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EC number: 216-644-2 | CAS number: 1633-22-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- See read-across justification report, attached to "Toxicological information" section.
- Reason / purpose for cross-reference:
- read-across source
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- 106
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- 90
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Interpretation of results:
- other: non-corrosive
- Conclusions:
- Dibenzetano is estimated to be non corrosive.
- Executive summary:
Dibenzetano is estimated to be non corrosive, from the result of the source study (see read-across justification report).
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- See read-across justification report, attached to "Toxicological information" section.
- Reason / purpose for cross-reference:
- read-across source
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- 98.209
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Interpretation of results:
- other: No Category
- Conclusions:
- Dibenzetano is estimated to be non irritant, from the result of the source study. Based on this one the indication of the classification for Dibenzetano is as follows: Globally Harmonized System of Classification and Labelling of Chemicals: No Category.
- Executive summary:
Dibenzetano is estimated to be non irritant, from the result of the source study (see read-across justification report).
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- See read-across justification report, attached to "Toxicological information" section.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- corneas treated with 750 mg DPX-C (Di-Cloro-Di-p-Xililene)
- Value:
- 0.42
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- corneas treated with 750 mg DPX-C (Di-Cloro-Di-p-Xililene) (suspension) at 20% (w/v)
- Value:
- 0.57
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Interpretation of results:
- other: No Category
- Conclusions:
- Dibenzetano is estimated to be non irritant, from the result of the source study. Based on this one, the indication of the classification for Dibenzetano is as follows: Globally Harmonized System of Classification and Labelling of Chemicals: No Category.
- Executive summary:
Dibenzetano is estimated to be non irritant, from the result of the source study (see read-across justification report).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
According to the test performed and to the Regulation (EC) n. 1272/2008, Dibenzetano is not classified as irritating to the skin and to the eye.
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