Registration Dossier
Registration Dossier
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EC number: 620-459-6 | CAS number: 130841-23-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
- EC Number:
- 620-459-6
- Cas Number:
- 130841-23-5
- Molecular formula:
- C9H3Cl2F6NO3
- IUPAC Name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ciba-Geigy Ltd., Animal Production
- Age at study initiation: 7 - 8 weeks
- Weight at study initiation: 200 - 256 g
- Housing: the rats were individually housed in Macrolon cages type 3, with standardized soft wood bedding
- Diet (e.g. ad libitum): yes
- Water (e.g. ad libitum): yes
- Acclimation period: 5 days before exposure
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 22°C
- Humidity (%): ca. 55%
- Air changes (per hr): ca. 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Vehicle:
- other: liquid substance, used undiluted
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: one single dose
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Mortality:
- daily; a.m. and p.m. on working days
a.m. on weekend days - Clinical signs:
- daily
- Body weight:
- immediatly before application and on days 7 and 14
- Gross pathology:
- the animals were submitted to a gross necropsy at the end of the observation period
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
