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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reliability has been presented as 2 because similar to OECD Guideline protocol has been followed but not GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

1
Chemical structure
Reference substance name:
2-heptylcyclopentanone
EC Number:
205-273-1
EC Name:
2-heptylcyclopentanone
Cas Number:
137-03-1
Molecular formula:
C12H22O
IUPAC Name:
2-heptylcyclopentan-1-one
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
No details.

ENVIRONMENTAL CONDITIONS
No details.

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No details.
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No deaths occurred.
Clinical signs:
other: No clinical signs were observed.
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
other: Not acute harmful.
Remarks:
According to Regulation (EC) No. 1272/2008.
Conclusions:
An LD50 of >5000 mg/kg bw was obtained in the acute oral toxicity study with rats. Based on this result, the substance is not acute harmful.
Executive summary:

In an acute oral toxicity study performed equivalent to OECD 401 guideline, one group of 10 rats were orally exposed to the substance. The rats were observed for signs of toxicity and clinical signs for a period of 14 days. No deaths occurred and no clinical signs were observed. An LD50 of >5000 mg/kg bw was obtained in the acute oral toxicity study with rats. Based on this result, the substance is not acute harmful.

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