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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Description of key information

A TGD-approved handbook states that the notional solid structure has a dissociation constant of 3.6 at 25°C, suggesting that at the ambient pH of 3.6, half the gluconic acid molecules will exist in the form of the uncharged acid, and half as the anion.  At pH < 3.6, the undissociated form will predominate, and pH > 3.6 the anion will predominate.  Therefore, gluconic acid will exist predominantly in the form of the dissociated anion throughout the range of pH 4 to 9. 

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Additional information

Information regarding dissociation constant of 50% aqueous solution of gluconic acid was based on the notional solid structure and was sourced from two separate handbooks. Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (14th Ed.) and Ullmann's Encylopedia of Industrial Chemistry (7th Ed.) report that gluconic acid (free acid) has a dissociation constant of 3.6 and 3.7 at 25°C, respectively. Although the information from both sources is comparable, the data obtained from Ullmann’s handbook is not TGD-approved, and as such is of Klimish-4 reliability and is not considered valid.