Thiazolidine-2,4-dione

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from review article or handbook

Data source

Reference

Reference Type:

review article or handbook

Title:

Tetrahydrothiophene [MAK Value Documentation, 2010a]

Author:

MAK Value Documentation

Year:

2012

Bibliographic source:

Tetrahydrothiophene [MAK Value Documentation, 2010a]. The MAK Collection for Occupational Health and Safety. 292–303; 2012.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

An eye irritation potential of Tetrahydrothiophene (CAS No: 110-01-0) was assessed in six albino rabbits to observed its irritating effects.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Tetrahydrothiophene

Cas Number:

110-01-0

Molecular formula:

C4H8S

IUPAC Name:

Tetrahydrothiophene

Test material form:

solid

Details on test material:

- Name of test material (as cited in study report): tetrahydrothiophene
- Molecular formula: C4H8S
- Molecular weight: 88.1732 g/mol
- Substance type: organic
- Physical state: Solid
- Smiles notation: C1CCSC1
- InChl: 1S/C4H8S/c1-2-4-5-3-1/h1-4H2

Specific details on test material used for the study:

- Name of test material (as cited in study report): tetrahydrothiophene
- Molecular formula: C4H8S
- Molecular weight: 88.1732 g/mol
- Substance type: organic
- Physical state: Solid
- Smiles notation: C1CCSC1
- InChl: 1S/C4H8S/c1-2-4-5-3-1/h1-4H2

Test animals / tissue source

Species:

rabbit

Strain:

other: Albino

Details on test animals or tissues and environmental conditions:

No Data Available

Test system

Vehicle:

not specified

Controls:

other: The untreated eyes served as controls.

Amount / concentration applied:

Amount: 0.1 ml
concentration applied:100mg

Duration of treatment / exposure:

24hours

Observation period (in vivo):

24hours

Number of animals or in vitro replicates:

6

Details on study design:

- Area of exposure: conjunctival sac of one of both eyes

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24 h

Score:

0

Reversibility:

fully reversible

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

The instillation caused pain and blepharospasms. Severe inflammation, chemosis and slightly deepened folds of the iris were observed during the first four hours. Twenty-four hours after the treatment, only mild inflammation of the conjunctiva was still visible

Applicant's summary and conclusion

Interpretation of results:

other: Not irritating

Conclusions:

The test material Tetrahydrothiophene (CAS No: 110-01-0) was considered to be not irritating to the eye of six albino rabbits.

Executive summary:

An eye irritation potential of Tetrahydrothiophene (CAS No: 110-01-0) was assessed in six albino rabbits to observed its irritating effects.

 

In this test, 0.1 ml (100 mg) tetrahydrothiophene was instilled into the conjunctival sac of one of both eyes and later ocular lesions were noted.

 

The instillation caused pain and blepharospasms. Severe inflammation, chemosis and slightly deepened folds of the iris were observed during the first four hours. Twenty-four hours after the treatment, only mild inflammation of the conjunctiva was still visible.

 

Since the ocular lesions were not persisted after 24 hours,the test materialTetrahydrothiophene (CAS No: 110-01-0)was considered to be not irritatingto the eye of six albino rabbits.