Registration Dossier
Registration Dossier
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EC number: 268-159-0 | CAS number: 68015-93-0
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 June 2000 - 28 June 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- The neat test substance was stored at room temperature.
- Dissociating properties:
- no
- No.:
- #1
- pKa:
- 0
- Remarks on result:
- not determinable
- Conclusions:
- The test substance was equilibrated in water and the water soluble fraction was titrated with a standard base. The average concentration of the four replicate test substance water soluble fractions was 2.41 x 10-5 mole /Liter. The test substance titration curve for each of the four replicates was indistinguishable from the blank curve. No significant differences among the replicate results were observed. The test substance was determined to have no observable dissociation.
- Executive summary:
The study was conducted in order to determine the dissociation constant of the test substance using the procedure outlined in the Organization for Economic Co-operation and Development (OECD) Guideline for Testing of Chemicals 112, "Dissociation Constants in Water, Titration Method". The dissociation of a substance in water is of importance in assessing its impact upon the environment.
The test substance was equilibrated in water and the water soluble fraction was then titrated with a standard base. The average concentration of four replicates of test substance in water was 2.41 x 10-5mole/Liter at 20°C. The test substance titration curve for each of the four replicates was indistinguishable from the blank. The test substance was determined to have no observable dissociation.
The reference substance, Benzoic Acid, average dissociation constant (pKa) at 20°C was determined to be 4.34 with a standard deviation of 0.01.
Reference
Description of key information
The test substance was determined to have no observable dissociation.
Key value for chemical safety assessment
- pKa at 20°C:
- 0
Additional information
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