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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD study or GLP defined.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Principles of method if other than guideline:
Method: other: Acute toxicity: oral, rat
GLP compliance:
not specified
Test type:
other: Acute toxicity: oral; rat
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,5-naphthylenediamine
EC Number:
218-817-8
EC Name:
1,5-naphthylenediamine
Cas Number:
2243-62-1
Molecular formula:
C10H10N2
IUPAC Name:
1,5-naphthylenediamine
Details on test material:
IUCLID4 Test substance: no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Lutrol
Doses:
500; 550; 600; 800; 1000; 1500 mg/kg bw.
No. of animals per sex per dose:
10/sex/dose
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
634 mg/kg bw
Mortality:
see: remarks on results
Clinical signs:
see:remarks on results
Body weight:
see:remarks on results

Any other information on results incl. tables

Mortality and symptoms:

 Dose (mg/kg bw.)  Sex  No. of mortalities  No. of animals with symptoms No. of animals used  Timepoint of death  Start of symptoms Diminuated general condition  Narcosis  Rough hair loss of bw.after one week 
 500  female  0  0  10            
 550  female  2  10  10  3 -6d 2h  +  +  +  +
 600  female  7  10  10  24h-5d   2h  +  +  +  +
 800  female  9  10  10  24h-2d   2h  +  +  +  +
 1000  female  9  10  10  2 -3d   2h  +  +  +  +
 1500  female  10  10  10  4h-2d   2h  +  +  +  +

Applicant's summary and conclusion

Executive summary:

Female Wistar rats were treated by gavage with one single dose of the test substance Alphamin ( 500; 550; 600; 800; 1000; 1500 mg/kg bw.).

10 rats per dose group were treated and observed for 14 days.

Following symptoms were observed: narcosis, rough hair, diminuated general condition, weight loss after the first week of experiment.

No macroscopical pathological findings were observed in the authopsy.

The LD50 was 634 mg/kg bw.