Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined. Insufficient data documentation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974

Materials and methods

Principles of method if other than guideline:
other: Akute toxicity, s.c., rat
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,5-naphthylenediamine
EC Number:
218-817-8
EC Name:
1,5-naphthylenediamine
Cas Number:
2243-62-1
Molecular formula:
C10H10N2
IUPAC Name:
1,5-naphthylenediamine
Details on test material:
IUCLID4 Test substance: other TS: purity 98.7 %

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
body weight 120-140g

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
water
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
1 563 mg/kg bw
Mortality:
no detailed information given, exept LD50 = 1563 mg/kg bw.
Clinical signs:
no data
Body weight:
120-140g
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

Female Wistar rats (120 -140 g; no.of animals unknown) were injected s.c. once with the test substance suspension.

The LD 50 was 1563 mg/kg bw.