Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

A specific toxicokinetic study is not available. Information on toxicokinetic properties is compiled from experimental toxicity and physico-chemistry studies.

The UVCB-substance consists of water-insoluble, high-molecular weight (>700 Da) components. It is a solid with a glass transition temperature of 105°C. The substance is soluble in organic solvents such as methylethylketone. It is poorly soluble in ethanol. The substance has inherent reactivity if dissolved in an organic solvent. It lacks reactivity if applied as a solid or as an aqueous suspension.

Local reactions with a delayed onset were observed when testing for acute dermal toxicity (5000 mg/kg bw, applied in olive oil for 24h). Local reactions also limited the highest concentration (in methyl ethyl ketone) that could be tested in the Local lymph node assay. In the in-vitro study for the skin irritation hazard assessment, no indication of any skin irritation potential was observed. In the in-vivo (and in-vitro) eye irritation study, no indication of an eye irritation potential was observed.

No indication of reactivity or systemic uptake was observed at the limit dose in the subacute gavage study or the teratogenicity/developmental toxicity study performed with a suspension in aqueous carboxymethyl cellulose.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information