Registration Dossier
Registration Dossier
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EC number: 231-149-1 | CAS number: 7440-39-3
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Data waiving:
- exposure considerations
- Justification for data waiving:
- a short-term toxicity study does not need to be conducted because exposure of humans via inhalation in production and/or use is not likely as based on the provided thorough and rigorous exposure assessment
- Justification for type of information:
- According to Regulation (EC) 1907/2006 Annex XI (weight of evidence), testing for sub-chronic inhalation toxicity is not considered to be required, for the following reasons: - BaCl2 is highly water soluble (375 g/L at 20°C) at a pH around 6.5. Therefore, no pH-related effects need to be assumed upon contact with respiratory tract epithelia, and any lung overload associated with inert particles can obviously be excluded. In consequence, local effects are not anticipated for barium dichloride. - In accordance with ECHA guidance on information requirements and chemical safety assessment-chapter R.8: characterisation of dose [concentration]-response for human health, November 2012, a DNEL for systemic effects could be derived by route-to-route extrapolation from a 90-day oral toxicity study in rats with BaCl2.
Data source
Materials and methods
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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