Registration Dossier
Registration Dossier
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EC number: 225-035-0 | CAS number: 4621-04-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- April, 1975
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study meets the EC Standards (conducted equivalent to OECD 402). Non GLP. Deviations: lack of study design details in the report, no details on test material, no details on test animals and environmental conditions. Only a very short description is reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- (lack of study design details in the report, no details on test material, no details on test animals and environmental conditions
- GLP compliance:
- no
- Remarks:
- not present at the time of performance
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): 75-82, p-isopropyl cyclohexanol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
No data
ENVIRONMENTAL CONDITIONS
No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- No data.
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- No abnormalities were observed.
- Body weight:
- No data.
- Gross pathology:
- No data.
- Other findings:
- Moderate redness was observed in five animals and marked redness was observed in the other 5 animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal toxicity study with rats, performed equivalent to OECD 402 guideline, an LD50 >5000 mg/kg bw was determined.
- Executive summary:
P-isopropyl cyclohexanol was tested in an acute dermal toxicity study with rabbits, performed equivalent to OECD 402 guideline. No deaths occurred.
Moderate redness was observed in five animals and marked redness was observed in the other 5 animals.
Based on the results, an LD50 >5000 mg/kg bw was determined.
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