Butane-1,2,3,4-tetracarboxylic acid

Endpoint summary

Description of key information

Biodegradation in Water:

Biodegradability of test chemical Butane-1,2,3,4-tetracarboxylic acid is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The predicted value for biodegradation is 86 % by BOD parameter in 28 days therefore, it is concluded that this test chemical Butane-1,2,3,4 -tetracarboxylic acid is readily biodegradable.

Biodegradation in water and Sediment:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound butane-1,2,3,4-tetracarboxylic acid (CAS No.  1703-58-8). If released in to the environment, 21.2 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of chemical Butane-1,2,3,4 -tetracarboxylic acid in water is estimated to be 2.329 days (55.9 hrs). The half-life ( 2.329 days estimted by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of butane-1,2,3,4-tetracarboxylic acid in sediment is estimated to be 20.95 days ( 503 hrs) indicates that Butane-1,2,3,4 -tetracarboxylic acid is not persistent in sediment.

Biodegradation in Soil :

The half-life period of Butane-1,2,3,4- tetracarboxylic acid (CAS No.1703 -58 -8) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 78.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Butane-1,2,3,4 -tetracarboxylic acid in soil is estimated to be 4.66 days (112 hrs). Based on this half-life value of Butane-1,2,3,4 -tetracarboxylic acid , it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water:

Predicted data for the target compound Butane-1,2,3,4-tetracarboxylic acid (CAS No. 1703 -58 -8) and supporting weight of evidence studies for its read across substance with log were reviewed for the biodegradation end point which are summarized as below.

Biodegradability of test chemical Butane-1,2,3,4-tetracarboxylic acid is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The predicted value for biodegradation is 86 % by BOD parameter in 28 days therefore, it is concluded that this test chemical Butane-1,2,3,4 -tetracarboxylic acid is readily biodegradable.

In a another prediction using the Estimation Programs Interface Suite (EPI suite, 2017) was run to predict the biodegradation potential of the test compound Butane-1,2,3,4- tetracarboxylic acid ( CAS no. 1703 -58 -8) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical butane-1,2,3,4-tetracarboxylic acid is expected to be readily biodegradable.

In supporting weight of evidence study from seconadry source ( Jcheck) 2017 for read across chemical 1,10 -Decanedioic acid ( CAS no. 111 -20 -6) the experiment was carried out to test biodegradability by taking three parameters into consideration namely BOD, TOC and HPLC. The inoculums used for this experiment was activated sludge at 30mg/Concentration. The initial concentration of read across chemical taken was 100 mg/L.The biodegradability test was carried out for 28 days. The percent biodegradation of read across chemical obtained was 89 % by BOD parameter and 100% by parameter TOC and HPLC. All percentages are high, so it is concluded that read across chemical 1, 10-Decanedioic acid is readily biodegradable.

On the basis of above results of target chemical Butane-1,2, 3,4 -tetracarboxylic acid ( From OECD QSAR tool box. v3.3 and EPI suite, 2017 ) and for its read across substance from seconadary source it can be concluded that the target chemical Butane-1, 2, 3, 4- tetracarboxylic acid isexpected to be readily biodegradable in nature.

Biodegradation in water and Sediment:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound butane-1,2,3,4-tetracarboxylic acid (CAS No.  1703-58-8). If released in to the environment, 21.2 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of chemical Butane-1,2,3,4 -tetracarboxylic acid in water is estimated to be 2.329 days (55.9 hrs). The half-life ( 2.329 days estimted by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of butane-1,2,3,4-tetracarboxylic acid in sediment is estimated to be 20.95 days ( 503 hrs) indicates that Butane-1,2,3,4 -tetracarboxylic acid is not persistent in sediment.

Biodegradation in Soil :

The half-life period of Butane-1,2,3,4- tetracarboxylic acid (CAS No.1703 -58 -8) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 78.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Butane-1,2,3,4 -tetracarboxylic acid in soil is estimated to be 4.66 days (112 hrs). Based on this half-life value of Butane-1,2,3,4 -tetracarboxylic acid , it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.