Sulphoacetic acid

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Short term toxicity test was carried out to study the effects of Sulphoacetic acid on Daphnia magna.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (as cited in study report): Sulfoacetate (Sulphoacetic acid)
- Molecular formula (if other than submission substance): C2H4O5S
- Molecular weight (if other than submission substance): 140.115 g/mol
- Substance type: Organic
- Physical state: solid
- Purity: no data
- Impurities (identity and concentrations): no data

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: Water Flea
- Source: LAB

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

809 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mobility

Conclusions:

The Effective concentration EC50 to 50% of Daphnia Magna is 809 mg/L for 24 hrs at which immobility was observed.
On the basis of the value obtained it can concluded that the Sulphoacetic acid is not toxic to Daphnia Magna.

Executive summary:

Short term toxicity to aquatic invertebrates was carried out to study the effects of Sulphoacetic acid. The Effective concentration EC50 to 50% of Daphnia Magna is 809 mg/L for 24 hrs at which immobility was observed.

On the basis of the value obtained it can be concluded that the Sulphoacetic acid is not toxic to Daphnia Magna at environmentally relevant concentrations and can be considered as “not classified” under CLP regulation.

Description of key information

Short term toxicity to aquatic invertebrates was carried out to study the effects of Sulphoacetic acid. The Effective concentration EC50 to 50% of Daphnia Magna is 809 mg/L for 24 hrs at which immobility was observed.

On the basis of the value obtained it can be concluded that the Sulphoacetic acid is not toxic to Daphnia Magna at environmentally relevant concentrations and can be considered as “not classified” under CLP regulation.

 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

809 mg/L

Additional information

Six studies including predicted data from validated tools and experimental data from peer reviewed journal for toxicity to aquatic algae endpoint of test chemical sulfoacetic acid (123-43-3) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:

 

Experimental data from peer reviewed journalWater Research1978 suggests that the Short term toxicity to aquatic invertebrates was carried out to study the effects of Sulphoacetic acid.

The Effective concentration EC50 to 50% of Daphnia Magna is 809 mg/L for 24 hrs at which immobility was observed.

 

Above results is supported by prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the toxicity to Daphnia magna for Sulphoacetic acid (CAS no.123-43-3) EC50 value was estimated 205.95 mg/kg bw for Daphnia magna.

 

In another prediction by Using the EPI Suite ECOSAR version 1.11, the short term toxicity on Daphnia magna was estimated for Sulphoacetic acid (CAS no. 123-43-3) on the basis of the effects observed in a freshwater system. The lethal concentration LC50 value for Sulphoacetic acid (CAS no. 123-43-3) estimated to be 192000 mg/l for daphnia magna for 48 hrs. exposure duration.

 

Another prediction done Using Battery algorithm model of Danish QSAR Short-term toxicity to Daphnia magna forSulphoacetic acid estimated to beEC50 1606.093 mg/L at 48 hrs.

All above prediction results for target are further supported by experimental data of read across chemical Malonic acid (Cas no. 123-43-3). The effective concentration EC50 value for Daphnia magna when exposed to Malonic acid for 48 Hour is 275 mg/l. on the basis of obtained value it can be concluded that Malonic acid is not considered as toxic to Daphnia magna at environmentally relevant concentrations.

 

Another experimental data of read across substance Succinic acid (110-15-6) from Journal of the Water Pollution Control Federation 1980 also indicates that the Effective concentration to 50% organisms (EC50) for Daphnia magna is 374.2 mg/l based on immobilisation effects.

Thus based on the effect concentrations which is in the range 205.95 mg/l to 2850000 give the conclusion that test substance Sulphoacetic acid (CAS no. 123-43-3) was likely to be non-toxic to aquatic algae at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP classification criteria.