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EC number: 204-627-2 | CAS number: 123-43-3
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Endpoint summary
Administrative data
Description of key information
Acute oral toxicity study was done in rat using sulfoacetic acid (123-43-3). LD50 was considered to be 3160 mg/kg body weight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from chemidplus and GSBL database.
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of Sulfoacetic acid was performed in Rat
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material : Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight : 140.115g/mole
- Substance type:organic
- Physical state:solid - Species:
- rat
- Strain:
- Sherman
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - Fasting period before study: Rats were no fasted before experiment.
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3160 mg/kg
- No. of animals per sex per dose:
- 5 animal /dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- The LD 50 was derived from the course of the curve mortality versus log of the dose graphically determined.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 160 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- Mortality observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Acute oral toxicity study was done in rat using sulfoacetic acid (123-43-3). LD50 was considered to be 3160 mg/kg body weight.
- Executive summary:
Acute oral toxicity test was performed in Sherman rats and observed for 14 days. No fasting of rats was done before experiment. 5 animals per dose were given dose by gavage and LD50 was derived from the course of the curve mortality versus log of the Dose graphically determined. After the experiment, the LD 50 value for sulfoacetic acid (123-43-3) was considered to be 3160 mg/kg.
Based on the value, sulfoacetic acid was considered to be non-toxic to rats and can be considered to be “not classified”as per the CLP regulations.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 160 mg/kg bw
- Quality of whole database:
- Data is Klimicsh 2 and from chemidplus and GSBL database
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity
In different studies, sulfoacetic acid (123-43-3).has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for sulfoacetic acid. The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In experimental study given by U.S. National Library of Medicine (ChemIDplus A TOXNET Database, 2017) and GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States, 2017. Acute oral toxicity test was performed in Sherman rats and observed for 14 days. No fasting of rats was done before experiment. 5 animals per dose were given dose by gavage and LD50 was derived from the course of the curve mortality versus log of the Dose graphically determined. After the experiment, the LD 50 value for sulfoacetic acid (123-43-3) was considered to be 3160 mg/kg.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for sulfoacetic acid. The LD50 was estimated to be 3160 mg/kg bw when Sprague-Dawley male and female rats were orally exposed with sulfoacetic acid
In another prediction done by SSS (2017) using the Danish QSAR with log kow as the primary descriptor, the acute oral toxicity was estimated for sulfoacetic acid. The LD50 was estimated to be 3800 mg/kg bw in rats (Reliability index: 0.77) orally exposed with sulfoacetic acid.
Also it is further supported by experimental study given by U.S. National Library of Medicine (ChemIDplus A TOXNET Database, 2017) on structurally similar read across substance Propionic acid(79 -09 -4), rats were treated with Propionic acid orally. 50% mortality was observed in treated mice at 2600 mg/kg bw. Therefore, LD50 was considered to be 2600mg/kg bw when rats were treated with Propionic acid orally.
Also it is further supported by experimental study given by U.S. National Library of Medicine (ChemIDplus A TOXNET Database, 2017) on structurally similar read across substance adipic acid(124-04-9)rats were treated with adipic acid orally. No mortality was observed in treated mice at 11000 mg/kg bw. Therefore, LD50 was considered to be > 11000mg/kg bw when rats were treated with adipic acid(124-04-9)orally
Thus, based on the above studies and predictions on sulfoacetic acid (123-43-3) and its read across substances, it can be concluded that LD50 value is 3160mg/kg bw. Thus, comparing this value with the criteria of CLP regulation sulfoacetic acid (123-43-3)can be “Not classified” of acute oral toxicity.
Justification for classification or non-classification
Thus, based on the above studies and predictions on sulfoacetic acid (123-43-3) and its read across substances, it can be concluded that LD50 value is 3160mg/kg bw. Thus, comparing this value with the criteria of CLP regulation sulfoacetic acid (123-43-3)can be “Not classified” of acute oral toxicity.
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