Registration Dossier
Registration Dossier
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EC number: 204-627-2 | CAS number: 123-43-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from chemidplus and GSBL database.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study in Rat .Test material: Sulfoacetic acid
- Author:
- U.S .National library of medicine
- Year:
- 2 017
- Bibliographic source:
- ChemID plus A TOXNET DATABASE.2017
- Reference Type:
- secondary source
- Title:
- Determination of acute oral toxicity.
- Author:
- German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany (Länder)
- Year:
- 2 017
- Bibliographic source:
- GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States,2017
- Reference Type:
- secondary source
- Title:
- Determination of acute oral toxicity.
- Author:
- United States trademark owned and licensed under authority of the U.S. Government
- Year:
- 2 016
- Bibliographic source:
- RTECS, Registry of Toxic Effects of Chemical Substances,2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of Sulfoacetic acid was performed in Rat
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sulphoacetic acid
- EC Number:
- 204-627-2
- EC Name:
- Sulphoacetic acid
- Cas Number:
- 123-43-3
- Molecular formula:
- C2H4O5S
- IUPAC Name:
- 2-sulfoacetic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material : Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight : 140.115g/mole
- Substance type:organic
- Physical state:solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material : Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight : 140.115g/mole
- Substance type:organic
- Physical state:solid
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - Fasting period before study: Rats were no fasted before experiment.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3160 mg/kg
- No. of animals per sex per dose:
- 5 animal /dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- The LD 50 was derived from the course of the curve mortality versus log of the dose graphically determined.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 160 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- Mortality observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Acute oral toxicity study was done in rat using sulfoacetic acid (123-43-3). LD50 was considered to be 3160 mg/kg body weight.
- Executive summary:
Acute oral toxicity test was performed in Sherman rats and observed for 14 days. No fasting of rats was done before experiment. 5 animals per dose were given dose by gavage and LD50 was derived from the course of the curve mortality versus log of the Dose graphically determined. After the experiment, the LD 50 value for sulfoacetic acid (123-43-3) was considered to be 3160 mg/kg.
Based on the value, sulfoacetic acid was considered to be non-toxic to rats and can be considered to be “not classified”as per the CLP regulations.
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