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Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from chemidplus and GSBL database.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute oral toxicity study in Rat .Test material: Sulfoacetic acid
Author:
U.S .National library of medicine
Year:
2017
Bibliographic source:
ChemID plus A TOXNET DATABASE.2017
Reference Type:
secondary source
Title:
Determination of acute oral toxicity.
Author:
German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany (Länder)   
Year:
2017
Bibliographic source:
GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States,2017
Reference Type:
secondary source
Title:
Determination of acute oral toxicity.
Author:
United States trademark owned and licensed under authority of the U.S. Government
Year:
2016
Bibliographic source:
RTECS, Registry of Toxic Effects of Chemical Substances,2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of Sulfoacetic acid was performed in Rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphoacetic acid
EC Number:
204-627-2
EC Name:
Sulphoacetic acid
Cas Number:
123-43-3
Molecular formula:
C2H4O5S
IUPAC Name:
2-sulfoacetic acid
Test material form:
solid
Details on test material:
- Name of test material : Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight : 140.115g/mole
- Substance type:organic
- Physical state:solid
Specific details on test material used for the study:
- Name of test material : Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight : 140.115g/mole
- Substance type:organic
- Physical state:solid

Test animals

Species:
rat
Strain:
Sherman
Sex:
not specified
Details on test animals or test system and environmental conditions:
- Fasting period before study: Rats were no fasted before experiment.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
3160 mg/kg
No. of animals per sex per dose:
5 animal /dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
The LD 50 was derived from the course of the curve mortality versus log of the dose graphically determined.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 160 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
Mortality observed
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
Acute oral toxicity study was done in rat using sulfoacetic acid (123-43-3). LD50 was considered to be 3160 mg/kg body weight.
Executive summary:

Acute oral toxicity test was performed in Sherman rats and observed for 14 days. No fasting of rats was done before experiment. 5 animals per dose were given dose by gavage and LD50 was derived from the course of the curve mortality versus log of the Dose graphically determined. After the experiment, the LD 50 value for sulfoacetic acid (123-43-3) was considered to be 3160 mg/kg.

Based on the value, sulfoacetic acid was considered to be non-toxic to rats and can be considered to be “not classified”as per the CLP regulations.