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Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from RTECS

Data source

Reference
Reference Type:
secondary source
Title:
RTECS - AJ4900000
Author:
RTECS - United States trademark owned and licensed under authority of the U.S. Government
Year:
1997
Bibliographic source:
RTECS, Registry of Toxic Effects of Chemical Substances, last updated 1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Standardized Draize test
Principles of method if other than guideline:
To assess the ocular irritation potential of sulfoacetic acid in rabbits according to Standard Draize test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphoacetic acid
EC Number:
204-627-2
EC Name:
Sulphoacetic acid
Cas Number:
123-43-3
Molecular formula:
C2H4O5S
IUPAC Name:
2-sulfoacetic acid
Test material form:
solid
Details on test material:
- Name of test material : Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight : 140.115g/mole
- Substance type:organic
- Physical state:solid
Specific details on test material used for the study:
- Name of test material: Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight: 140.115g/mole
- Substance type: organic
- Physical state: solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
20 mg
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
no data available
Details on study design:
TEST SITE
- Area of exposure:Administration onto the skin

SCORING SYSTEM:Draize

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Moderately irritating to skin

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Sulfoacetic acid was moderately irritating to rabbit skin after 24 hours of exposure.
Hence, sulfoacetic acid can be considered to be moderate dermal irritant.
Executive summary:

The dermal irritation potential of sulfoacetic acid was assessed in rabbits according to Standard Draize test. 20 mg of sulfoacetic acid was applied on to the skin of rabbits. The rabbits were exposed to the test chemical for 24 hours and observed for signs of irritation.

Sulfoacetic acid was moderately irritating to rabbit skin after 24 hours of exposure.

Hence, sulfoacetic acid can be considered to be moderate dermal irritant.