Octane-1-thiol

Toxicity to aquatic algae and cyanobacteria

Description of key information

MOE (2004) gives a 48 hr toxicity of octane-1-thiol to algae of ErC50: 0.03867 mg/l and NOEC: 0.010412 mg/L. This is supported by read across from dodecane-1-thiol. The NOEC, EC10 and EC50 for biomass and growth rate are below the solubility limit of dodecane-1-thiol as well as the limit of detection of analysis for the experiment, which corresponds to a concentration of  <14.5 ug/l. 

Key value for chemical safety assessment

EC50 for freshwater algae:

0.039 mg/L

EC10 or NOEC for freshwater algae:

0.01 mg/L

Additional information

MOE (2004) is only available as a summary and so it has not been fully evaluated. This study is used as a critical study for the SIDS endpoint and is used in the IUCLID Data Set for Octane-1-thiol (2004). The study has been given a Klimisch score 2 - reliable with restrictions (Klimisch et al, 1997) in the IUCLID Data Set and is here considered as Klimisch 2 until the reference is available as being sponsored by MOE one can consider the study as relevant.

This is supported by read across from dodecane-1 -thiol. Thiebaud (1999) is a static, 72 -hour study which follows OECD guideline 201. It cannot be verified that the concentrations were maintained within 80% of the nominal concentrations, because the limit of solubility of dodecane-1-thiol is below the limit of analysis. The study has been given a reliability of 2 - reliable with restrictions (Klimisch et al 1997).