Octane-1-thiol

Specific investigations: other studies

Administrative data

Endpoint:

specific investigations: other studies

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

26-5-1983 to 10-06-1983

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study is classified as reliable with restrictions because it does appear to have largely followed OECD guideline 403 recommendations.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: other guideline: Phillips Protocol 3, a-d

Deviations:

yes

Remarks:

The protocol 3 a-d did not describe methods for measuring particle size. Additionally the age of the mice was unclear, as it was referred to as "young adults"

GLP compliance:

not specified

Type of method:

in vivo

Endpoint addressed:

respiratory irritation

Test material

Test material information

Constituent 1

Reference substance name:

Octane-1-thiol (CAS # 111-88-6)

IUPAC Name:

Octane-1-thiol (CAS # 111-88-6)

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Vehicle:

unchanged (no vehicle)

Duration of treatment / exposure:

1 minute

Doses / concentrations

Remarks:

Doses / Concentrations:
nominal concentration of 1.51 mg/L (actual concentration 157.75 ppm)
Basis:

No. of animals per sex per dose:

5

Results and discussion

Details on results:

All animals appeared normal at the terminal sacrifice with the exception of one male observed with a pale white focus on the surface of the lungs.

Any other information on results incl. tables

Male mice of the outbred SPF (CD-1, COBS) strain weighing 20-25 g were selected as the experimental animals.  A group of four animals was  exposed, head only, to vaporized test material at a nominal concentration of 1.51 mg/L (actual concentration  157.75 ppm).  Each animal was  housed  in an individual plethysmograph to permit monitoring of respiration. After the animals became acclimatized they were exposed to  vaporized test  material for one minute and permitted to recover for 10 minutes while being exposed to room air only. Following this the animals were exposed to vaporized test material for 1 minute, then to room air for 5 minutes.  During this time their respiratory patterns were continually monitored.

Applicant's summary and conclusion

Conclusions:

Based on these results, exposure to octane-1-thiol at a concentration of 157.75 ppm via inhalation failed to produce upper airway irritancy in mice.

Executive summary:

In an acute oral toxicity study, groups of 5 male and 5 female mice were exposed (head only) to vapourized octane-1-thiol at concentrations of 1.51 mg/L (157.75 ppm or 1510 mg/m³) for 1 minute. Following exposure, the mice were exposed to room air that did not contain the test material. No signs of upper airway irritancy were detected in any of the test animals following necroscopy.

 

This study received a Klimisch score of 2 and is classified as reliable with restrictions because no mention of GLP is included in the study report.