Octane-1-thiol

Endpoint summary

Additional information

No toxicokinetic, metabolism or distribution studies were identified for octane-1-thiol. In the WHO document (http://www.inchem.org/documents/jecfa/jecmono/v44jec09.htm), the applicability domain for the alkyl and aromatic thiols evaluated is much wider for simple, alkyl thiols and is based on the presumed common metabolism of these thiols. Simple thiols are metabolized via several different pathways in mammalian systems that include: S-methylation, resulting in a methyl thioether that would undergo S-oxidation; reaction with glutathione to form mixed disulfides (the likely form in circulation); and, especially for the low molecular weight thiols [methanethiol was presented as the example], oxidative desulfuration to yield CO and SO₄.