Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

No toxicokinetic, metabolism or distribution studies were identified for octane-1-thiol. In the WHO document (, the applicability domain for the alkyl and aromatic thiols evaluated is much wider for simple, alkyl thiols and is based on the presumed common metabolism of these thiols. Simple thiols are metabolized via several different pathways in mammalian systems that include: S-methylation, resulting in a methyl thioether that would undergo S-oxidation; reaction with glutathione to form mixed disulfides (the likely form in circulation); and, especially for the low molecular weight thiols [methanethiol was presented as the example], oxidative desulfuration to yield CO and SO4.