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EC number: 203-918-1 | CAS number: 111-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981-01-21 to 1981-02-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was classified as reliable with restrictions because it was well-documented and generally followed OECD Guidelines 420.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- yes
- Remarks:
- method of oral application (gavage) was not detailed; highest doses exceed limit test dose; the recommended doses of 5, 50, 300 and 2000 mg/kg were not used
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UBTL Division, University of Utah Research Institute
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Octane-1-thiol (CAS # 111-88-6)
- IUPAC Name:
- Octane-1-thiol (CAS # 111-88-6)
- Details on test material:
- - Name of test material (as cited in study report): Phillips n-octyl mercaptan (Octane-1-thiol)
- Other: UBTL Sample# 80M 05450-3
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Simonson Lab or other reputable animal breeder
- Weight at study initiation: 150 to 300 grams
- Fasting period before study: 1 day
- Housing: individually in either stainless steel cages with screen floors and pans or in polycarbonate boxes using wood shavings for bedding
- Diet (e.g. ad libitum): Wayne's Lab-B, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.4 ro 22.7
- Humidity (%): 30 to 60% (median 45%)
- Air changes (per hr): 15 exchanges
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 1981-01-27 To: 1981-02-10
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE: no vehicle
MAXIMUM DOSE VOLUME APPLIED: 3360 mg/kg (4.0 mL/kg)
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: - Doses:
- 1680, 2100, 2688, or 3360 mg/kg bw (2, 2.5, 3.2, or 4 mL/kg bw)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: twice daily during the first 3 days and approximately 24 hours thereafter for 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: pharmacological symptoms, body weight, external and internal examination - Statistics:
- probit analysis
Results and discussion
- Preliminary study:
- Results from the preliminary study were not provided.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 436 mg/kg bw
- 95% CL:
- 2 108 - 2 831
- Remarks on result:
- other: 2436 mg/kg bw = 2.9 mL/kg bw
- Mortality:
- One death at 1680 mg/kg, three deaths at 2100 mg/kg, six deaths at 2688 mg/kg and nine deaths at 3360 mg/kg
- Clinical signs:
- other: Animals that died prior to sacrifice exhibited lacrimation, bleeding from eyes, and docile behaviour to no activity prior to death.
- Gross pathology:
- In the first dose level three animals showed abnormal tissue in some of the following tissue: lung, liver, stomach, intestines, kidney, gonads, and ovaries. Eight animals in the second dose level showed abnormalities in some the following tissue: lungs, liver, adrenals, stomach, spleen, kidneys, and intestines. All of the animals in the two highest dose levels showed abnormalities in some of the following tissue: heart, lungs, liver, stomach, spleen, kidneys, intestines, adrenals, esophagus, bladder, and gonad.
Any other information on results incl. tables
Summary of Responses
Dose (mg/kg) |
No. of Animals Exposed |
No. of Animals that Died |
% Mortality |
1680 |
10 |
1 |
10 |
2100 |
10 |
3 |
30 |
2688 |
10 |
6 |
60 |
3360 |
10 |
9 |
90 |
Mean Body Weights (gm)
Group # |
Dose (mg/kg) |
No. of Animals Surviving |
Fasted |
Day 7 |
Day 14 |
1 |
1680 |
9 |
176 |
177 |
211 |
2 |
2100 |
7 |
174 |
163 |
215 |
3 |
2688 |
4 |
162 |
117 |
140 |
4 |
3360 |
1 |
171 |
120 |
176 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity study, groups of fasted, albino rats (5/sex) were given a single oral dose of octane-1-thiol at doses of 1680, 2100, 2688, or 3360 mg/kg bw and observed for 14 days. The oral LD50 was determined to be 2436 mg/kg bw in males and females. The test material fell outside the range of toxicity categories and was not classified by EU standards.
- Executive summary:
In an acute oral toxicity study, groups of fasted, albino rats (5/sex) were given a single oral dose of octane-1-thiol at doses of 1680, 2100, 2688, or 3360 mg/kg bw and observed for 14 days.
Mortality occurred at all dose levels. There were treatment related clinical signs and necropsy findings at all dose levels. Body weights decreased by day 7 in the three highest dose levels but increased by day 14 at all dose levels for the surviving animals. The oral LD50 was determined to be 2436 mg/kg bw in males and females. The test material fell outside the range of toxicity categories and was not classified by EU standards.
This study received a Klimisch score of 2 and was classified as reliable with restrictions because it was well-documented and generally followed OECD Guidelines 420.
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