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Administrative data

Endpoint:
pH
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04/2021
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2021-03-01 - 2021-04-30
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
Lot 2103311210
Key result
Water solubility:
ca. 1 562 g/L
Conc. based on:
test mat.
Incubation duration:
> 24 - <= 120 h
Temp.:
20 °C
pH:
ca. 6.2
Conclusions:
The mean watersolubility of Guanidinium thiocyanate is 1562 g/L at 20 +/- 0.5 °C.
The pH of the satureted solution is 6.2.
Executive summary:

The solubility of Guanidinium Thiocyanate was determined in water at a temperature of 20 ± 0.5 °C according to OECD guideline 105 (Shake Flask) with restrictions.
The results are presented in the following table:



Solubility of guanidinium thiocyanate in water at 20 ± 0.5 °C













Determined pH6.2
Mean solubility [g/L]1562


The repeated samplings indicate the required reproducibility (relative standard deviation below 15%).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2021
Report date:
2021

Materials and methods

Test guideline
Guideline:
other: OECD 105
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Guanidinium thiocyanate
EC Number:
209-812-1
EC Name:
Guanidinium thiocyanate
Cas Number:
593-84-0
Molecular formula:
CH5N3.CHNS
IUPAC Name:
amino(imino)methanaminium thiocyanate
impurity 1
Reference substance name:
unknown
IUPAC Name:
unknown
Test material form:
solid: bulk
Specific details on test material used for the study:
Lot2103311210

Results and discussion

pH value
Key result
pH value:
6.2
Temp.:
20 °C
Concentration:
1 562 g/L

Applicant's summary and conclusion

Conclusions:
The pH of a satureted solution of GTC is 6.2
Executive summary:

In a watersolubility study according to OECD 105 with GTC the pH of the saturated solution was determined.