Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Guanidine Thiocyanate was proven to be inherently biodegradable in an OECD guideline 302B study.

Additional information

The biodegradability of Guanidinium Thiocyanate exposed to activated sludge of a municipal sewage treatment plant was investigated under aerobic static conditions according to OECD guideline 302B.

Based on the data of the individual DOC determinations the test substance reached a biodegradation of 46 % after 28 days.

No significant elimination of the test substance due to adsorption to the activated sludge, on the glass surface or other physico-chemical processes was found as determined by means of DOC measurements 3 h after the start of the test.

The test was considered valid, since the degradation of the reference compound reached more than 70 % within 14 days of incubation.


Based on the results Guanidinium Thiocyanate can be termed as inherently biodegradable under the conditions of the OECD guideline no. 302, since more than 20 %, but less than 70 % degradation was attained after 28 days of contact time.


Supporting information is available for the read-across substance Guanidine nitrate. In a ready ready biodegradability study according to OECD Guideline 301 C (Modified MITI Test), the test substance was not biodegradable under test conditions. Additionally under environmental conditions in surface water, Guanidine nitrate was found to be inherently biodegradable.