Registration Dossier
Registration Dossier
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EC number: 209-812-1 | CAS number: 593-84-0
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish:
96-h-LC50: 89.1 mg/l nominal (100 % a.i)
Long-term toxicity to fish:
NOEC: 2.23 mg/L (nominal)
Basis for effect:decreased egg production, increased time to first spawn and development of overt goiter.
Short-term toxicity to aquatic invertebrates:
48h-EC50: 42.4 mg/l (nominal, 100 % a.i.).
Long-term toxicity to aquatic invertebrates:
21d-NOEC: 1.94 mg/l (nominal, 100 % a.i.).
Toxicity to aquatic algae and cyanobacteria:
EC50: 130 mg/l (nominal).
Toxicity to microorganisms:
EC50: 1380 mg/L (nominal)
10d-EC10: 200 mg/L (nominal)
Additional information
Short-term toxicity to fish:
The acute toxicity of Guanidine thiocyanate was tested in a 96-h toxicity test in Poecilia reticulate (Guppy). The 96-h-LC50 was 89.1 mg/l nominal (100 % a.i)
Long-term toxicity to fish:
Read-across from Potassium thiocyanate. NOEC corrected for molecular weight.
Short-term toxicity to aquatic invertebrates:
The 48h-acute toxicity of Guanidine thiocyanate to aquatic invertebrates (Daphnids) was studied. A 48h-EC50 based on immobilization was found to be 42.4 mg/l (nominal, 100 % a.i.).
Long-term toxicity to aquatic invertebrates:
A study according to OECD TG 211 with Ammonium thiocyanate (CAS-No. 1762-95-4) was taken as read-across source for the Endpoint "Long-term toxicity to aquatic invertebrates".
The effect concentrations determined for Ammonium thiocyanate (CAS-No. 1762-95-4) were adjusted to the molecular weight of Guanidine thiocyanate (CAS-No. 593-84-0).
Toxicity to aquatic algae and cyanobacteria:
In a 72 hour acute toxicity study, the cultures of Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) were exposed to Guanidine Thiocyanate under static conditions.
EC50values based on measurement of in vivo chlorophyll fluorescence was 130 mg/l (nominal).
Toxicity to microorganisms:
The acute toxicity to bacteria of Guanidine Thiocyanate was tested in a Bacterial Luminescence Assay (LUMIStox (Dr. Lange GmbH, Dusseldorf, Germany)).Cultures of Photobacterium phosphoreum were exposed to 5 different concentrations for 30 min. The EC50 was determined to be 1380 mg/L (nominal) by bioluminescence measurement.
The biodegradability of Guanidinium Thiocyanate exposed to activated sludge of a municipal sewage treatment plant was investigated under aerobic static conditions according to OECD guideline 302B. The test substance reached a biodegradation of 46 % after 28 days and is thus inherently biodegradable. As the test substance is proven to be inherently biodegradable, according toTGDs, Chapter R.10,the respective test concentration can be used to derive a NOEC.
According to the degradation curve, the inocculum was active until the end of test (28d). As most of degradation occured until day10 (42% degradation), 10d-EC10, as a worst case assumption, was estimated to be 200mg/L.
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