Registration Dossier
Registration Dossier
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EC number: 200-562-9 | CAS number: 63-68-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 600 mg/L
Additional information
No experimental data is available for L-methionine.
The toxicity to fish by D,L-methionine was determined in a GLP guideline study in accordance with OECD 203. The LC50 for the fresh water fish Brachydanio rerio after 96 h was determined to be >3200 mg/l as all animals were alive at this concentration of D,L-methionine.
Read-across of the D,L-methionine study to L-methionine was used due to structural similarities and the physico-chemical similarity according to Reach regulation (Annex XI, 1.5). Further, L-methionine is present in a considerable amount in racemic methionine (approximatly 50%). Taking this into account it can be concluded that the LC50 of L-methionine is > 1600 mg/l as a worst case approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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