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Environmental fate & pathways

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Description of key information

Hydrolysis

HYDROWIN v2.00 program of Estimation Programs Interface prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was determined to be 3950 yrs at pH 7.0 (at 25ᵒC) respectively, indicating that it is stable in water.

Additional information

Hydrolysis

Predicted data of the test chemical and various experimental supporting studies for its structurally similar read across substance were reviewed for the hydrolysis end point which are summarized as below:

 

In a prediction done using the HYDROWIN v2.00 program of Estimation Programs Interface (Modelling database, 2011) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was determined to be 3950 yrs at pH 7.0 (at 25ᵒC) respectively, indicating that it is stable in water

 

In a supporting weight of evidence study from handbook (2008) and secondary source, the half-life of the test chemical was determined at different pH range.The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH 4, 7 and 9, respectively. Although the half-life value of test chemical was mentioned, but was reported to be stable at a pH 4, 7 and 9 at 25⁰C temperature. This indicates that the test chemical is hydrolytically stable.

 

For the test chemical, the half-life of the test chemical was determined (secondary source, 2001). The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). Percentage degradation of test chemical was determined to be 3.91%, 1.085% and 4.78% at pH 4.0, 7.0 and 9.0 & at a temperature of 50°C, respectively and the half-life value of test chemical was determined to be > 1 yr. Since the chemical is not degradable less than 10 % in this test condition, it is presumably stable in water. Thus based on this, test chemical is considered to be hydrolytically stable.

 

On the basis of the above results of the test chemical, it can be concluded that the test chemical is stable in water.