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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From June 22 to July 7, 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study with few acceptable restrictions. Not fully GLP compliant (no accreditation claimed) but quality system in place.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
14C-radiolabelled material was used; pH not measured; no preliminary study.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
not specified
Remarks:
GLP like
Type of method:
column elution method
Specific details on test material used for the study:
- Name of test material (as cited in study report): dibenzyltoluene
- Radiochemical purity (if radiolabelling): > 99%
- Specific activity (if radiolabelling): 0.15 mCi/mmol (0.55GBq/mmol)
- Locations of the label (if radiolabelling): on the benzyl nucleus
- Physical state: liquid
- Analytical purity: 0.1mCi/mL in isopropanol
- Lot/batch No.: 0595
- Storage condition of test material: under nitrgen at-25°C in the dark
Water solubility:
18 µg/L
Temp.:
20 °C
pH:
ca. 7
Remarks on result:
other: pH cannot be measured due to the test design. No ionisable group on the molecule.
Details on results:
Temperature: 19.9 - 20.1°C

Two assays were conducted:

Assay 1:
recirculating flow rate 25ml/h
Water solubility: 18.33 µg/L, s = 1.012
Time to attain saturation plateau = 22 hours

Assay 2:
recirculating flow rate 12.5 ml/h
Water solubility: 17.54 µg/L, s = 0.125
Time to attain saturation plateau = 22.5 hours

The difference between assay results was 4.85%. Therefore, assays agreed with a repeatability of less than 30%
Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The substance was found to be practically insoluble in water. The water solubility was found to be 18 µg/L.
Executive summary:

The water solubility of 14C-radiolabelled dibenzyltoluene was determined according to EU Method A.6 (column elution method). It was found to be 18 µg/L (at 20°C).

Description of key information

The water solubility of 14C-radiolabelled dibenzyltoluene (Dibenzylbenzene, ar-methyl derivative) was determined according to EU Method A.6 (column elution method). It was found to be 18 µg/L (at 20°C).

Key value for chemical safety assessment

Water solubility:
0.018 mg/L
at the temperature of:
20 °C

Additional information