Registration Dossier
Registration Dossier
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EC number: 274-403-7 | CAS number: 70210-06-9
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Log Pow < 0.3
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.3
- at the temperature of:
- 25 °C
Additional information
Partition coefficient was determined by OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method).
The study was performed using a HPLC with a C18 column. Seven reference substances with different retention times and thiourea for the determination ofthe dead time were used to produce a calibration curve, since retention time on hydrophobic columns and Pow are
correlated. The reference substances were chosen consequent to the pre-test.
One vial was filled with the reference substance mix and one vial with the test substance solution. The vials were analysed using the HPLC with the program described above. One injection from the solvent blank methanol/water 65/35 (%v/v) was made. Three injections were measured from the reference substance mix, three injections from the test substance and again, three injections from the reference substance mix.
For each reference substance, the capacity factor, K, was calculated from the retention time of thiourea and the retention time of the respective reference substance.
A calibration function (log K versus log Pow, linear fit) was determined using the literature values for Pow of the reference substances and the retention times in the six determinations.
The chromatogram of the test substance gave one peak at 1.7 min.
Therefore, the corresponding log Pow is stated as < 0.3 (lowest log Pow of reference substances used is 0.3 (log Pow of 2-Butanone)).
The peak lies in the dead time of the method and not within the range of log Pows of the reference substances. Therefore, the corresponding log Pow is stated as < 0.3 (lowest log Pow of reference substances used is 0.3 (log Pow of 2-Butanone)).
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