Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-622-8 | CAS number: 144-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Skin Irritation:
The dermal irritation potential of piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
Piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated to be highly irritating/corrosive to the skin of New Zealand White rabbits
Based on the estimated results, piperazine 2-hydroxypropane-1,2,3-tricarboxylate can be classified under the category “Category 1B” as per CLP regulation
Eye Irritation:
The ocular irritation potential of piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
Piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated to be irritating to the eyes of New Zealand White rabbits.
Based on the estimated results, piperazine 2-hydroxypropane-1,2,3-tricarboxylate can classified under the category “Category 2” as per CLP regulation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox v3.3 and the QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR toolbox v3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Piperazine citrate - Molecular formula: C12H30N6•Cl2H16O14 - Molecular weight: 642.76 g/mole - Substance type: Organic - Physical state: Solid
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data available
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 h
- Details on study design:
- no data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Irritation was observed
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- The dermal irritation potential of piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor. Piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated to be highly irritating/corrosive to the skin of New Zealand White rabbits Based on the estimated results, piperazine 2-hydroxypropane-1,2,3-tricarboxylate can be classified under the category “Category 1B” as per CLP regulation
- Executive summary:
The dermal irritation potential of piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated using OECD QSAR toolbox v 3.3 with logPow as the primary descriptor.
Piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated to be highly irritating/corrosive to the skin of New Zealand White rabbits
Based on the estimated results, piperazine 2-hydroxypropane-1,2,3-tricarboxylate can be classified under the category “Category 1B” as per CLP regulation
Reference
Estimation method: Takes mode value from the 6 nearest neighbours
Domain logical expression:Result: Out of Domain
((((((((((((("a" or "b" or "c" or "d" or "e" ) and ("f" and ( not "g") ) ) and ("h" and ( not "i") ) ) and "j" ) and "k" ) and ("l" and ( not "m") ) ) and "n" ) and "o" ) and "p" ) and "q" ) and ("r" and ( not "s") ) ) and "t" ) and ("u" and "v" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Not categorized AND Secondary amines by OECD HPV Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Aliphatic Amines AND Not categorized by US-EPA New Chemical Categories
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Alcohol OR Carboxylic acid OR Piperazine OR Saturated heterocyclic amine OR Saturated heterocyclic fragment by Organic Functional groups ONLY
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Alcohol OR Carboxylic acid OR Overlapping groups OR Piperazine OR Saturated heterocyclic amine OR Saturated heterocyclic fragment by Organic Functional groups (nested) ONLY
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Alcohol OR Alpha-hydroxyacid OR Amine OR Carbonic acid derivative OR Carboxylic acid OR Carboxylic acid derivative OR Heterocyclic compound OR Hydroxy compound OR Secondary aliphatic amine OR Secondary amine by Organic functional groups, Norbert Haider (checkmol) ONLY
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as Non binder, non cyclic structure AND Non binder, without OH or NH2 group by Estrogen Receptor Binding
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as Non binder, impaired OH or NH2 group OR Non binder, MW>500 by Estrogen Receptor Binding
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OECD
Domain logical expression index: "i"
Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Direct Acylation Involving a Leaving group OR Acylation >> Direct Acylation Involving a Leaving group >> Acetates OR Acylation >> Direct Acylation Involving a Leaving group >> Anhydrides OR Acylation >> Ring Opening Acylation OR Acylation >> Ring Opening Acylation >> alpha-Lactams OR Michael addition OR Michael addition >> Polarised Alkenes OR Michael addition >> Polarised Alkenes >> Polarised alkene - amides OR Michael addition >> Polarised Alkenes >> Polarised alkene - cyano OR Michael addition >> Polarised Alkenes >> Polarised alkene - esters OR SN2 OR SN2 >> SN2 reaction at a sulphur atom OR SN2 >> SN2 reaction at a sulphur atom >> Thiols OR SN2 >> SN2 reaction at sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Allyl acetates and related chemicals by Protein binding by OECD
Domain logical expression index: "j"
Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis ONLY
Domain logical expression index: "k"
Referential boundary: The target chemical should be classified as Alcohol AND Carboxylic acid AND Piperazine AND Saturated heterocyclic amine AND Saturated heterocyclic fragment by Organic Functional groups ONLY
Domain logical expression index: "l"
Referential boundary: The target chemical should be classified as Acid, aliphatic attach [-COOH] AND Alcohol, olefinic attach [-OH] AND Alcohol-acid Carbon [HO-C-COOH] AND Aliphatic Carbon [C] AND Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Amino, aliphatic attach [-N<] AND Amino, aliphatic attach [-NH-] AND Carbonyl, aliphatic attach [-C(=O)-] AND Hydroxy, aliphatic attach [-OH] AND Miscellaneous sulfide (=S) or oxide (=O) AND Multi alcohol AND Olefinic carbon [=CH- or =C<] AND Tertiary Carbon by Organic functional groups (US EPA)
Domain logical expression index: "m"
Referential boundary: The target chemical should be classified as Phosphine oxide [O=P] OR Succinate salt OR Tertiary Carbon by Organic functional groups (US EPA)
Domain logical expression index: "n"
Referential boundary: The target chemical should be classified as Alcohol AND Alpha-hydroxyacid AND Amine AND Carbonic acid derivative AND Carboxylic acid AND Carboxylic acid derivative AND Heterocyclic compound AND Hydroxy compound AND Secondary aliphatic amine AND Secondary amine by Organic functional groups, Norbert Haider (checkmol) ONLY
Domain logical expression index: "o"
Referential boundary: The target chemical should be classified as Alcohol AND Alpha-hydroxyacid AND Amine AND Carbonic acid derivative AND Carboxylic acid AND Carboxylic acid derivative AND Heterocyclic compound AND Hydroxy compound AND Secondary aliphatic amine AND Secondary amine by Organic functional groups, Norbert Haider (checkmol) ONLY
Domain logical expression index: "p"
Referential boundary: The target chemical should be classified as Alcohol AND Alpha-hydroxyacid AND Amine AND Carbonic acid derivative AND Carboxylic acid AND Carboxylic acid derivative AND Heterocyclic compound AND Hydroxy compound AND Secondary aliphatic amine AND Secondary amine by Organic functional groups, Norbert Haider (checkmol) ONLY
Domain logical expression index: "q"
Similarity boundary:Target: C1CNCCN1_C1CNCCN1_C1CNCCN1_OC(=O)CC(O)(CC(O)=O)C(O)=O_OC(=O)CC(O)(CC(O)=O)C(O)=O
Threshold=20%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain logical expression index: "r"
Referential boundary: The target chemical should be classified as Known precedent reproductive and developmental toxic potential AND Not known precedent reproductive and developmental toxic potential AND Piperazine-, dioxane-, morpholine-, tetrahydrothiopyran-like derivatives and cyclohexanamine (17c) by DART scheme v.1.0
Domain logical expression index: "s"
Referential boundary: The target chemical should be classified as Alpha-hydroxy and alkoxyacetic acid derivatives (22b) OR C1 to C4 non-branched alkyl alcohols- sub category (25a) by DART scheme v.1.0
Domain logical expression index: "t"
Referential boundary: The target chemical should be classified as Very fast by Bioaccumulation - metabolism half-lives ONLY
Domain logical expression index: "u"
Parametric boundary:The target chemical should have a value of log Kow which is >= -2.15
Domain logical expression index: "v"
Parametric boundary:The target chemical should have a value of log Kow which is <= -0.258
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- data is from OECD QSAR toolbox v3.3 and the QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR toolbox v3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Piperazine citrate - Molecular formula: C12H30N6•Cl2H16O14 - Molecular weight: 642.76 g/mole - Substance type: Organic - Physical state: Solid
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- no data available
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- 4 days after application
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- no data available
- Other effects / acceptance of results:
- no data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4 days
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- irritation was observed
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The ocular irritation potential of piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor. Piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated to be irritating to the eyes of New Zealand White rabbits. Based on the estimated results, piperazine 2-hydroxypropane-1,2,3-tricarboxylate can classified under the category “Category 2” as per CLP regulation.
- Executive summary:
The ocular irritation potential of piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
Piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated to be irritating to the eyes of New Zealand White rabbits.
Based on the estimated results, piperazine 2-hydroxypropane-1,2,3-tricarboxylate can classified under the category “Category 2” as per CLP regulation.
Reference
Estimation method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((("a" or "b" or "c" or "d" or "e" ) and "f" ) and "g" ) and "h" ) and "i" ) and ("j" and ( not "k") ) ) and ("l" and "m" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Aliphatic Amines AND Not categorized by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Alcohol OR Carboxylic acid OR Piperazine OR Saturated heterocyclic amine OR Saturated heterocyclic fragment by Organic Functional groups ONLY
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Alcohol OR Carboxylic acid OR Overlapping groups OR Piperazine OR Saturated heterocyclic amine OR Saturated heterocyclic fragment by Organic Functional groups (nested) ONLY
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Acid, aliphatic attach [-COOH] OR Alcohol, olefinic attach [-OH] OR Alcohol-acid Carbon [HO-C-COOH] OR Aliphatic Carbon [C] OR Aliphatic Carbon [CH] OR Aliphatic Carbon [-CH2-] OR Amino, aliphatic attach [-N<] OR Amino, aliphatic attach [-NH-] OR Carbonyl, aliphatic attach [-C(=O)-] OR Hydroxy, aliphatic attach [-OH] OR Miscellaneous sulfide (=S) or oxide (=O) OR Multi alcohol OR Olefinic carbon [=CH- or =C<] OR Tertiary Carbon by Organic functional groups (US EPA) ONLY
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Alcohol OR Alpha-hydroxyacid OR Amine OR Carbonic acid derivative OR Carboxylic acid OR Carboxylic acid derivative OR Heterocyclic compound OR Hydroxy compound OR Secondary aliphatic amine OR Secondary amine by Organic functional groups, Norbert Haider (checkmol) ONLY
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis ONLY
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as Alcohol AND Carboxylic acid AND Piperazine AND Saturated heterocyclic amine AND Saturated heterocyclic fragment by Organic Functional groups ONLY
Domain logical expression index: "h"
Similarity boundary:Target: C1CNCCN1_C1CNCCN1_C1CNCCN1_OC(=O)CC(O)(CC(O)=O)C(O)=O_OC(=O)CC(O)(CC(O)=O)C(O)=O
Threshold=30%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain logical expression index: "i"
Similarity boundary:Target: C1CNCCN1_C1CNCCN1_C1CNCCN1_OC(=O)CC(O)(CC(O)=O)C(O)=O_OC(=O)CC(O)(CC(O)=O)C(O)=O
Threshold=10%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain logical expression index: "j"
Referential boundary: The target chemical should be classified as Non-Metals by Groups of elements
Domain logical expression index: "k"
Referential boundary: The target chemical should be classified as Alkali Earth by Groups of elements
Domain logical expression index: "l"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.67
Domain logical expression index: "m"
Parametric boundary:The target chemical should have a value of log Kow which is <= -0.579
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation
Predicted data for the target and experimental studies for its read across substance piperazine (CAS 110-85-0), which is also its parents compound, were reviewed for classifying the skin irritation potential of the substance piperazine citrate and are presented below as weight of evidence approach:
In a prediction done by SSS (2017), the dermal irritation potential of piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor. Piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated to be highly irritating/corrosive to the skin of New Zealand White rabbits. Based on the estimated results, piperazine 2-hydroxypropane-1,2,3-tricarboxylate can be classified under the category “Category 1B” as per CLP regulation.
The dermal irritation potential of test article was determined according to the OECD 439 test guideline followed for this study. The Mean % tissue viability compared to negative control (n=3) of Tripiperazine dicitrate [ CAS: 144-29-6] was determined to be 97.1%. Thus, Tripiperazine dicitrate [CAS: 144-29-6] was considered to be not irritating to the human skin.
Skin irritation study was carried out in 3 (2 males and 1 female) Weisser Wiener white rabbits for parent compound piperazine; CAS 110-85-0; (European Union Risk Assessment Report: Piperazine -3rd Priority List Volume: 56; Final Report, 2005) according to OECD Guideline 404 to assess its irritation potential. The rabbits were kept individually and the fur was removed by close clipping at least 15 hours pre dosing. About 500mg of piperazine in a 50% aqueous solution (assumingly piperazine base) was applied to a 6.25 cm2 gauze patch and applied to the skin and covered with a semi-occlusive dressing. After exposure for 4 hours, the test substance was removed, and the skin reaction evaluated after 30-60 minutes, 24, 48 and 72 hours, respectively. Observations at 48 and 72 hours revealed severe erythema and necrosis in all animals. Hence the test chemical Piperazine (CAS No: 110-85-0) was considered as a strong skin irritant.
Results of some skin irritation studies summarized in RTECS- TK7800000, last updated 2015, have confirmed the effects of piperazine (CAS 110-85-0) on skin as follows:
Skin irritation test was conducted to evaluate the skin irritancy of chemical piperazine. The test chemical piperazine was applied to the skin of rabbit with concentration of 500 mg in open test. Mild irritant effects were known in the test. Hence, the chemical piperazine is mildly skin irritating to the rabbit skin when 500 mg of chemical was applied to the rabbit skin.
Another skin irritation test was conducted to evaluate the skin irritancy of chemical piperazine. The test chemical piperazine was applied to the skin of rabbit with concentration of 0.01 mL. Moderate irritant effects were known in the test. Hence, the chemical piperazine was moderately irritating to the rabbit skin when 0.01 mL of chemical was applied to the rabbit skin.
Based on the available data for the parent compound, piperazine (CAS 110-85-0), it is observed that the substance is moderate to highly irritating to skin but as per classification under Globally Harmonised System the substance is classified as skin corrosive under category 1B. Thus, considering the estimation of target and GHS classification of the parent compound and by applying the weight of evidence approach it can be assumed that there is a possibility of piperazine citrate to be corrosive to skin. Hence piperazine citrate is likely to be classified as a skin corrosive under category 1B.
Eye Irritation
Predicted data for the target and experimental studies for its read across substance piperazine (CAS 110-85-0), which is also its parents compound, were reviewed for classifying the eye irritation potential of the substance piperazine citrate and are presented below as weight of evidence approach:
In a prediction done by SSS (2017), the ocular irritation potential of piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor. Piperazine 2-hydroxypropane-1,2,3-tricarboxylate was estimated to be irritating to the eyes of New Zealand White rabbits. Based on the estimated results, piperazine 2-hydroxypropane-1,2,3-tricarboxylate can classified under the category “Category 2” as per CLP regulation.
Various studies were conducted on the parent compound piperazine (CAS 110-85-0) to evaluate its eye irritation potential in rabbits which are as follows:
An ocular irritation study (Am. J. Ophtalmol. 29, 1363-1372, 1946) was performed by Carpenter CP and Smyth HF on rabbits to assess the irritation potency of the test chemical, piperazine. Normal rabbit eyes were selected on basis of visual inspection after staining with a 5% aqueous solution of fluorescein, and flushed out with distilled water 20 seconds after application. After a 2-hour resting period, 0.005 ml of a 5% solution was applied to the centre of the cornea while the lids were retracted. About one minute later the lids were released, and 18-24 hours later the eyes were stained with fluorescein and the injury scored. Together with sulphuric acid and ammonium hydroxide, piperazine was given the grade 9 on a scale ranging from 1 to 10, with necrosis covering 60-90% of the cornea. An aqueous solution containing 1-5% piperazine (assumingly piperazine base) caused etching and necrosis of the rabbit cornea. Hence piperazine was considered to be irritating to rabbit eyes.
Eye irritation test was conducted (RTECS- TK7800000, last updated 2015) to evaluate the eye irritancy of chemical piperazine. The test chemical piperazine was instilled into the eye of rabbit with concentration of 250µg for 24-hrs. Severely irritating effects were observed during the test. Hence, the chemical piperazine was considered to be severely eye irritating to the rabbit eyes.
Further an eye irritation study was carried (obtained from GESTIS database, 2016) out on rabbits to assess the irritation potency of Piperazine. 1 drop of the concentrated liquid (5 % solution) was instilled into rabbit eyes and effects were observed. 1 drop of the concentrated liquid caused serious damage, which was considered persistent, to rabbits' eyes. Even an only 5 % solution caused damage which was assessed as grade 9 on a scale from 1 to 10. These effects were assessed to be corrosive in nature. Hence it was inferred that 5% or concentrated solution of Piperazine causes severe irritation to rabbit eyes.
The ocular irritation potential of test article was determined according to the OECD 492 test guideline. The mean % tissue viability of Tripiperazine dicitrate[CAS: 144-29-6] was determined to be 97.3%. Thus, Tripiperazine dicitrate[CAS: 144-29-6] was considered to be not irritating to MatTek EpiOcular Tisssue Model OCL-200.
Based on the available data for the parent compound, piperazine (CAS 110-85-0) and applying the weight of evidence approach, there is a possibility of piperazine citrate (which is the citric acid derivative of piperazine) to be irritating to eyes. Hence piperazine citrate is likely to be considered as an Eye irritant under category 2.
Justification for classification or non-classification
Based on the available data for the parent compound, piperazine and applying the weight of evidence approach, there is a possibility of piperazine citrate (which is the citric acid derivative of piperazine) to be corrosive to skin and irritating to eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
