Registration Dossier
Registration Dossier
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EC number: 225-184-1 | CAS number: 4702-90-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Test atmosphere generation not adequately described. Design in principle designed for vapours.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- 8h-exposure of rats to a test atmosphere generated by blowing air through a layer of the test substance, 7-day post-treatment observation period
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- EC Number:
- 225-184-1
- EC Name:
- 4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- Cas Number:
- 4702-90-3
- Molecular formula:
- C21H18N4O2
- IUPAC Name:
- 4,4'-methylylidenebis(5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one)
- Details on test material:
- - Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 172 g (male), 167 g (female)
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h - Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- The nominal concentration could be usuallycalculated as quotient of the amount of test substance weight loss during the exposure, which is given in the raw data, and the amount of air used during the exposure.
- Duration of exposure:
- 8 h
- Concentrations:
- ca. 7.39 mg/l
- No. of animals per sex per dose:
- 12
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: prior to and at the end of study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 7.39 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: dust
- Mortality:
- no mortalities
- Clinical signs:
- other: no abnormalities observed
- Body weight:
- d1: mean 172 g (male), 167 g (female)
d7: mean 198 g (male), 189 g (female)
control animals:
d1: mean 169 g (male), 157 g (female)
d7: mean 197 g (male), 180 g (female) - Gross pathology:
- no abnormalities found
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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