Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

 O-phthalonitrile is considered as non-irritating to the skin and the eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Skin irritation was tested using an internal standard method (BASF test). This study meets scientific standards with acceptable restrictions (limited documentation).Whiterabbits were used. 2 animals were treated for 1, 5 and 15 minutes and for 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the test substance. The test substance induced questionable erythema after 20 h occlusive exposure in 1/2 animals, which was reversible within 4 d. 15 min exposure did not cause any irritation effects.

Eye irritation was examined in a study comparable to OECD Guideline 405 with acceptable restrictions (limited documentation, reduced application volume). The study is however sufficient for evaluation of this endpoint. Irritation effects were not observed after 24 and 48 h. Equivalent effects to the talcum-treated eyes were observed on the day of application.

Justification for classification or non-classification

No classification suggested for irritation as criteria of regulation 1272/2008/EC are not met.