Registration Dossier
Registration Dossier
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EC number: 202-044-8 | CAS number: 91-15-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Ames Test; HPRT test, in vivo CA and occupational worker screening: negative
Additional information
ortho-Phthalodinitril was tested in the standard plate test and in the pre-incubation test with and without metabolic activation in S. typhimurium TA98, TA100, TA1535 and TA1537 at dose levels of 20 -5000 and 4 - 2500 µg/plate, respectively. The study was conducted similar to the OECD Guideline 471 and is reliable with restrictions. No increase in the number of revertants was detected in any strain with and without MA. Vehicle controls and positive controls were valid. Cytotoxicity was found depending on the strain and metabolic activation. Precipitation was reported.
Beyond this, no mutagenicity was found for ortho-Phthalonitril in an in-vitro mamalian cell genotoxicity study (HPRT Test). An in-vivo chromosomal aberration test did not find clastogenic activity. No hint for any mutagenic properties was found in human lycocytes in a occupational health investigation.
Justification for classification or non-classification
No classification suggested for mutagenicity as criteria of regulation 1272/2008/EC are not met.
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